Product Overview
[Drug Name]
Generic Name: Levoamlodipine Besylate Tablets
Trade Name: Zuoyi Levoamlodipine Besylate Tablets 5mg*14 Tablets
Pinyin Code: ZuoYi BenHuangSuanZuoAnLvDiPingPian 5mg*14 Tablets
[Main Ingredient]
The active ingredient of this product is levamlodipine besylate.
[Properties]
This product is white tablets.
[Indications/Main Functions]
1. Hypertension. 2. Angina pectoris.
[Precautions]
1. As with all calcium channel blockers, caution should be exercised in patients with impaired liver function. 2. For patients with renal failure, normal doses can be used. 3. This product is not suitable for dialysis.
[Drug Interactions]
Allergy to dihydropyridine calcium channel blockers.
[Pediatric Use]
No data are available for the use of this product in children.
[Use in Elderly Patients]
Older patients can use the normal dose. However, it is advisable to start with a lower dose and then gradually increase it.
[Use in Pregnant and Breastfeeding Women]
This product is recommended only when there are no safer alternatives and the disease itself poses a greater risk to the mother and child.
[Specifications]
5mg x 14 tablets (Zuoyi)
[Dosage and Administration]
Oral: 1. The initial dose for the treatment of hypertension and angina pectoris is 2.5mg once daily. The dose can be increased based on the patient's clinical response, up to a maximum of 5mg once daily. 2. No dose adjustment is required when this product is used in combination with thiazide diuretics, beta-blockers, and angiotensin-converting enzyme inhibitors.
[Adverse Reactions]
This product is well tolerated by patients. 1. Less common side effects include headache, edema, fatigue, insomnia, nausea, abdominal pain, flushing, palpitations, and dizziness. 2. Extremely rare side effects include itching, rash, dyspnea, weakness, muscle cramps, and indigestion. 3. Similar to other calcium antagonists, adverse reactions such as myocardial infarction and chest pain have been reported rarely, and these reactions cannot be clearly distinguished from the patient's underlying medical condition. 4. No abnormal laboratory parameters have been found to be associated with this product.
[Contraindications]
Allergic reactions to dihydropyridine calcium antagonists.
[Overdose]
Not yet known.
[Pharmacology and Toxicology]
Amlodipine besylate is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker). Cardiac and smooth muscle contraction depends on the entry of extracellular calcium ions into cells through specific ion channels. This product selectively inhibits the transmembrane entry of calcium ions into smooth muscle cells and cardiomyocytes, with a greater effect on smooth muscle than on myocardium. Its interaction with calcium channels is determined by the progressive rate of binding and dissociation between it and its receptor sites, resulting in a gradual onset of pharmacological action. This product is a peripheral arterial dilator, acting directly on vascular smooth muscle, reducing peripheral vascular resistance and thereby lowering blood pressure. At therapeutic doses, negative inotropic effects have been observed in vitro but not in whole animal studies. This product does not affect plasma calcium concentration.
[Pharmacokinetics]
Not yet known.
