Product Overview
【Drug name】
Generic name: Children's Paracetamol Huang Na Min Granules
Trade name: KuTong Children's Paracetamol Huang Na Min Granules 11 bags
Pinyin full code: KuTong XiaoErAnFenHuangNaMinKeLi
【Main ingredients】
Compound preparation. Please see the instructions for details
【Indications/Main functions】
KuTong Children's Paracetamol Huang Na Min Granules Efficacy: Suitable for relieving fever, headache, limb pain, sneezing, runny nose, nasal congestion, sore throat and other symptoms caused by children's common cold and influenza
【Specifications】
11 bags
【Usage and dosage】
Take with warm water. The dosage for children is shown in the table below.
Age (years) Weight (kg) Dosage per time (bag) Times per day
1-3 10-15 0.5-1
4-6 16-21 1-1.5 3 times a day
7-9 22-27 1.5-2
10-12 28-32 2-2.5
【Adverse reactions】
1. In a few cases, agranulocytosis, methemoglobinemia, allergic dermatitis (rash, skin itching, etc.), liver damage, thrombocytopenia, drowsiness, etc. may occur.
2. Long-term and large-scale use of the drug, especially in patients with impaired renal function, may cause renal colic or acute renal failure (oliguria, uremia) or chronic renal failure (analgesic nephropathy).
【Contraindications】
1. It is contraindicated for patients who are allergic to a component of this product.
2. It is contraindicated for patients with active peptic ulcer.
3. It is contraindicated for newborns or premature infants.
4. Pregnant and lactating women are prohibited from using this product.
【Precautions】
1. Do not take preparations containing this product and other antipyretic analgesics at the same time.
2. Do not take it in large quantities or for a long time to prevent damage to the hematopoietic system, liver, and kidneys. Those who do not have significant therapeutic effects should seek medical attention.
3. Use with caution in patients with impaired liver and kidney function.
4. Children must use it under adult supervision.
5. Please keep this drug out of reach of children.
【Drug Interactions】
1. Patients who use barbiturates (such as phenobarbital) or antispasmodics (such as belladonna) may suffer liver damage when using this product for a long time. 2. This product can enhance the toxicity of chloramphenicol when used together with chloramphenicol. 3. Large or long-term use of this product can reduce the synthesis of coagulation factors in the liver, so it can enhance the anticoagulant effect of anticoagulants. 4. Long-term and large-scale use of this product with aspirin, other salicylate preparations or other non-steroidal anti-inflammatory drugs can significantly increase the risk of renal toxicity.
【Drug use in children】
Not yet clear.
【Drug use in elderly patients】
Not yet clear.
【Drug use in pregnant and lactating women】
The acetaminophen and artificial bezoar in this product can pass through the placenta, which may have adverse effects on the fetus, and are toxic and teratogenic to the embryo; except for artificial bezoar, which is unknown, all other products can be secreted through breast milk, so pregnant and lactating women are prohibited from using it.
【Drug overdose】
In case of drug overdose (including toxic dose), symptoms such as nausea, vomiting, stomach pain or stomach cramps, diarrhea, anorexia, and hyperhidrosis may occur quickly, and may last for 24 hours. Liver function damage occurs within 2-4 days, manifested as pain in the liver area, hepatomegaly, and jaundice. In case of drug overdose, gastric lavage or vomiting should be performed, and the acetaminophen antagonist N-acetylcysteine should be given. Activated carbon should not be given because the latter can affect the absorption of the antagonist. N-acetylcysteine is initially given orally at 140 mg/kg according to body weight, and then 70 mg/kg once every 4 hours for a total of 17 times. In severe cases, it can be administered intravenously by dissolving the drug in 200 ml of 5% glucose injection. Antagonists should be used as early as possible. The effect is satisfactory if given within 12 hours, and the effect is poorer if given after 24 hours. Blood drug concentration should be tested during treatment, and other supportive therapies should be given.
【Pharmacology and Toxicology]
The acetaminophen in this product mainly produces analgesia by inhibiting the synthesis of prostaglandins (inhibiting prostaglandin synthase) and blocking the impulse of pain nerve endings. The latter may be related to the inhibition of the synthesis of prostaglandins or other substances that can sensitize pain receptors (5-hydroxytryptamine, bradykinin, etc.); the antipyretic effect is through the hypothalamic temperature regulation center to produce peripheral vasodilation, and it works by increasing skin blood flow, sweating and heat loss. Chlorpheniramine maleate is an antihistamine that competitively blocks histamine (H1) receptors, relieves allergic symptoms, and can relieve symptoms such as nasal congestion, runny nose, and sneezing caused by colds. Artificial bezoar has antipyretic and sedative effects.
【Pharmacokinetics】
After oral absorption, the acetaminophen in this product is evenly distributed in the body, and about 25% is bound to plasma proteins. The blood concentration reaches its peak 0.5-2 hours after oral administration. The half-life (t1/2) is generally 1-4 hours (average 2 hours). The half-life is not affected by renal insufficiency, but the half-life is prolonged in patients with liver insufficiency, newborns, and the elderly, while it is shortened in children. Acetaminophen can be secreted through breast milk; 90%-95% is metabolized in the liver, and the main metabolites are glucuronic acid, sulfuric acid, and cysteine conjugates. The intermediate metabolites are toxic to the liver and kidneys. It is mainly excreted from the kidneys in the form of glucuronic acid, and less than 5% is excreted in the urine in its original form.
【Packaging】
11 bags/box
【Validity period】
24 months
【Approval number】
National Medicine Standard H13023570
【Manufacturer】
Cangzhou Deneng Pharmaceutical Co., Ltd.
