Product Overview
[Drug name]
Generic name: Polycresol sulfonaldehyde vaginal suppository
Trade name: AnGe Polycresol sulfonaldehyde vaginal suppository 90mg*8s
Pinyin full code: AnGe JuJiaFenHuangQuanYinDaoShuan 9Omg*8s
[Main ingredients]
The main ingredient is polycresol sulfonaldehyde
[Properties]
This product is a white to light reddish brown suppository
[Indications/Main functions]
It is used to treat vaginitis, cervicitis and its associated symptoms (such as increased leucorrhea caused by bacterial, trichomonas and fungal infections), genital warts and pressure ulcers caused by the use of pessaries, etc.
[Specifications]
90mg*8 tablets (with 8 finger sleeves)
[Usage and dosage]
Depending on the condition, one vaginal test agent can be used every other day or every day, and the course of treatment is determined by the doctor. If the lesion is cauterized with its solution, a vaginal test agent is inserted on the day between two cauterizations. When using it, the patient is best to lie on his back, soak the test agent with water first, and then insert it deep into the vagina. It is usually appropriate to take the medicine before going to bed at night. Use sanitary belts together to prevent contamination of clothing and bedding. If used during surgery, vaginal plugs should be used monthly and removed 1-2 hours after surgery.
[Adverse Reactions]
In the early stage of medication, local leukemia symptoms sometimes occur, but they disappear quickly. Occasionally, there is a feeling of vaginal tightening and dryness. If any adverse events and/or adverse reactions occur during the use of this product, please contact your doctor.
[Contraindications]
It is contraindicated for patients who are allergic to any ingredient in this product. During pregnancy, polycresol sulfonaldehyde can only be used when absolutely necessary. At this time, the potential harm of the drug to mother and child should be fully considered. Although animal tests
show that this drug has no teratogenic effect, the results of human experiments have not yet been obtained, and it is not clear whether the active ingredients of this drug are contained in the breast milk of lactating women.
[Drug Interactions]
Drug interactions may occur if used with other drugs at the same time. Please consult a doctor or pharmacist for details.
[Precautions]
1. This product is for external use and should not be taken orally. 2. This product should avoid contact with the eyes. 3. This product will accelerate and enhance the repair process. If necrotic tissue falls off from the lesion after taking the medicine, sometimes even in large pieces, there is no need to be alarmed. 4. Stop treatment during menstruation; avoid sexual intercourse during treatment. Do not use irritating soap to clean the affected area. 5. Cotton fabrics and leather must be washed with water immediately before the preparation dries after contact with the liquid medicine. 6. The spots on the vaginal suppository are a natural phenomenon produced by its matrix and do not affect the use and efficacy of the drug, nor its tolerance.
【Children's Use】
There is still a lack of research data on the efficacy and safety of this product for children. Avoid contact with children.
【Elderly Patients' Use】
Not yet clear
【Overdose】
Not yet clear
【Pharmacology and Toxicology】
Polycresol sulfonaldehyde is a polymer of m-cresol sulfonic acid linked by methylene groups, with varying chain lengths. The pH of this solution is 0.6, and the pH rises to 2.0 after dilution of 1:200. Efficacy and mechanism of action: 1. Anti-bacterial, fungal and protozoan infections; 2. Selectively act on necrotic tissue and columnar epithelium and denature them, but have no effect on normal squamous epithelium; 3. Hemostatic effect by coagulating plasma proteins and significantly stimulating vasoconstriction. Polycresol sulfonaldehyde has a broad spectrum of antibacterial effects, including Gram-positive bacteria, Gram-negative bacteria and certain fungi, and is particularly worth mentioning that it is effective against Ghana, anaerobic bacteria and Trichomonas. There is no report of drug resistance for this product. More than 50 years of toxicological research, clinical experience has shown that polycresol sulfonaldehyde is non-toxic when used topically. Acute toxicity: The LD50 of mice is 360 mg/kg after intravenous administration and 2400 mg/kg after oral administration; the LD50 of rats is 400 mg/kg and 3500 mg/kg after intravenous and oral administration respectively. The LD50 of mice is 200 times the human therapeutic dose, and the LD50 of rats is 300 times the human therapeutic dose. Chronic toxicity: Rats and dogs were given 40 times and 9 times the human therapeutic dose for 3 months, respectively, and no relevant toxic effects were found. In the skin tolerance test of polycresol sulfonaldehyde on the depilated back of rats, polycresol sulfonaldehyde (4%, 11% and 36%) was applied in different concentrations in the first 10 days of the 14-day observation, which only caused transient skin redness, which lasted until the third application and then disappeared. Reproductive toxicity: Studies on pregnant rats and rabbits have shown that polycresol sulfonaldehyde has no embryotoxicity or teratogenicity. Mutagenicity/Carcinogenicity: There is no relevant study on the carcinogenicity of this product. The Ames test shows that polycresol sulfonaldehyde has no mutagenic effect. Although there are currently no research reports on the carcinogenicity of this product, no mutagenic or carcinogenic effects have been found in many years of clinical use.
