Product Overview
[Drug name]
Generic name: Indapamide Tablets
Trade name: Pingmei
English name: Indapamide Tablets
Chinese Pinyin: Yindapaan Pian
[Ingredients]
The main ingredient of this product is indapamide, and its chemical name is: N-(2-methyl-2,3-dihydro-1H-indolyl)-3-sulfamoyl-4-chloro-benzamide. Its structural formula is: Molecular formula: C16H16ClN3O3S Molecular weight: 365.83
[Properties]
This product is a sugar-coated tablet, which appears white after removing the sugar coating.
[Indications]
Anti-hypertension, has the effect of dilating vascular smooth muscle and diuresis, and is used for primary hypertension.
[Usage and Dosage]
Adults usually take it orally, 1 tablet at a time, once a day.
[Adverse reactions]
It is relatively mild and short-lived, and is dose-related. ⑴Less common reactions are: diarrhea, headache, loss of appetite, insomnia, nausea, and orthostatic hypotension. ⑵ Rarely, there are: allergic reactions such as rash and itching; hyponatremia, hypokalemia, and hypochloremic alkalosis.
[Contraindications]
Allergic to sulfonamides Severe renal insufficiency Hepatic encephalopathy Hypokalemia Usually, this drug should not be used in combination with lithium and non-antiarrhythmic drugs that can induce torsades de pointes (refer to drug interactions).
[Precautions]
① In order to reduce the possibility of electrolyte imbalance, it is advisable to use a smaller effective dose, and blood potassium, sodium and uric acid should be monitored regularly, pay attention to maintaining water and electrolyte balance, and pay attention to timely potassium supplementation. ② When used as a diuretic, it is best to give the drug once a morning to avoid getting up to urinate at night. ③ Anuria or severe renal insufficiency can induce azotemia. ④ Gout or hyperuricemia, at this time, blood uric acid can be further increased. ⑤ Liver dysfunction, diuresis can induce hepatic coma. ⑥ After sympathectomy, the antihypertensive effect will be enhanced at this time. ⑦ If this product is used and surgery is required, it is not necessary to stop using this product, but the anesthesiologist must be informed.
[Use in special populations]
Children's precautions: Not yet clear.
Precautions during pregnancy and lactation: There is no human study on the effect on pregnancy, and no problems have been found in animal studies. It is not clear whether this product is excreted into breast milk, but no problems have occurred in human use.
Precautions for the elderly: The elderly are more sensitive to antihypertensive effects and electrolyte changes, and often have changes in renal function, so caution must be exercised when using this product.
[Drug Interactions]
① The diuretic and natriuretic effects of this product are weakened when used with adrenocortical hormones; ② When used with amiodarone, it is easy to cause arrhythmia due to low blood potassium; ③ The anticoagulant effect of this product is weakened when used with oral anticoagulants; ④ The natriuretic effect of this product is weakened when used with non-steroidal anti-inflammatory analgesics; ⑤ The diuretic effect of this product is enhanced when used with dopamine; ⑥ The antihypertensive effect of this product is enhanced when used with other types of antihypertensive drugs; ⑦ The antihypertensive effect of this product is weakened when used with sympathomimetics; ⑧ When used with lithium agents, this product can increase blood lithium concentration and show signs of overdose; ⑨ When used with large doses of salicylates, dehydrated patients may develop acute renal failure; ⑩ When used with metformin, lactic acidosis is likely to occur.
[Pharmacological Actions]
It is a sulfonamide diuretic that works by inhibiting the reabsorption of water and electrolytes in the dilution segment of the distal renal tubular cortex. The antihypertensive effect is unclear, and its diuretic effect cannot explain the antihypertensive effect, because the dose of antihypertensive effect is much lower than the dose of diuretic effect. The possible mechanisms include the following aspects: regulating calcium influx in vascular smooth muscle cells; stimulating the synthesis of prostaglandins PGE2 and prostaglandins PGI2; reducing the hypersensitivity of blood vessels to vasopressor amines, thereby inhibiting vasoconstriction. This product has little or no effect on cardiac output, heart rate and rhythm when lowering blood pressure. Long-term use of this product rarely affects glomerular filtration rate or renal blood flow. This drug does not affect the metabolism of blood lipids and carbohydrates.
[Storage]
Shading, sealed storage.
[Specification]
2.5mg
[Packing specification]
2.5mg*15s*2 plates/box
[Validity period]
24 months.
[Approval number]
National medicine standard H10983096
[Manufacturer]
Company name: Jinan Gaohua Pharmaceutical Co., Ltd.
