Product Overview
[Drug name]
Generic name: Clomiphene Citrate Capsules
Trade name: Kanghe Pharmaceutical
English name: Clomifene Citrate Capsules
Chinese Pinyin: Juyuɑnsuɑn Lümifen Jiɑonɑnɡ
[Ingredients]
Clomiphene Citrate
[Properties]
This product is a capsule, the contents are white or off-white powder; odorless.
[Indications]
1. Treatment of female infertility without ovulation, suitable for those with a certain level of estrogen in the body; 2. Treatment of corpus luteum insufficiency; 3. Test ovarian function; 4. Detect male hypothalamus-pituitary-gonadal axis dysfunction; 5. Treatment of male infertility due to oligospermia.
[Usage and Dosage]
Oral 50 mg per day for 5 days. Start taking the medicine from the 5th day of the menstrual cycle. If the patient is amenorrhea, it should be taken on the 5th day of withdrawal bleeding with progesterone. Patients who ovulate but do not conceive after treatment can repeat the original course of treatment until conception, or repeat 3-4 courses. If the patient does not ovulate after treatment, the dose can be increased to 100 mg per day for 5 days in the next course of treatment. Some patients can ovulate only when the dose reaches 150 mg per day.
[Adverse Reactions]
1. The more common adverse reactions are: swelling, stomach pain, pelvic or lower abdominal pain (ovarian enlargement or cyst formation or ovarian fibroma enlargement, more obvious ovarian enlargement, generally occurs a few days after stopping the drug). 2. Less common are: blurred vision, double vision, flashes in front of the eyes, light sensitivity, decreased vision, yellowing of the skin and sclera. 3..Attention should be paid to the following reactions when they persist: hot flashes, breast discomfort, constipation or diarrhea, dizziness or vertigo, headache, increased menstrual flow or irregular bleeding, increased appetite and weight, hair loss, depression, mental tension, hyperactivity, insomnia, fatigue, nausea and vomiting, skin rashes, allergic dermatitis, urticaria, frequent urination, etc., and weight loss may also occur. There are very few reports of breast cancer and testicular cancer abroad.
[Contraindications]
Unexplained irregular vaginal bleeding, uterine fibroids, ovarian cysts, liver damage, depression, thrombophlebitis, etc. are contraindicated.
[Precautions]
1. Animal experiments have shown that this product can cause teratogenesis. During the medication period, the basal body temperature should be measured daily to monitor the patient's ovulation and conception. If conception occurs, the drug should be stopped immediately. 2. Use with caution in polycystic ovary syndrome. 3. During medication, the following tests should be performed as needed: 1) FSH and LH; 2) For long-term users, the 24-dehydrocholesterol level in plasma should be measured to find out whether the medication has an effect on cholesterol synthesis. 3) Plasma corticosteroid transfer protein level. 4) Serum thyroxine level. 5) Sex hormone binding globulin level. 6) Sodium sulfobromophthalein (BSP) liver function test. 7) Thyroxine binding globulin level (may increase). 4. During medication, attention should be paid to the following tests: Before each course of treatment, the size of the ovaries should be correctly estimated; basal body temperature should be measured every day, and estrogen and serum progesterone levels should be measured if necessary; urine pregnanediol level should be measured to determine whether ovulation has occurred; liver function should be measured before treatment, and fundus and slit lamp examinations should be performed for those who have been treated for more than 1 year; if visual impairment occurs during medication, the medication should be stopped immediately and corresponding examinations should be performed.
[Medication for special populations]
Children's precautions: Not yet clear.
Precautions during pregnancy and lactation: Animal experiments have teratogenic effects and fetal toxicity, and pregnant women are prohibited from using.
Precautions for the elderly: Not yet clear.
[Drug interactions]
Not yet clear
[Pharmacological action]
Anti-hormone drug. The mechanism of stimulating ovulation by this product is not fully understood. Since this product has a weak excitatory and strong antagonistic effect on estrogen, stimulating ovulation may be in the hypothalamus. First, antagonism is dominant. By competitively occupying the hypothalamic estrogen receptors, it interferes with the negative feedback of endogenous estrogen, promotes the secretion of luteinizing hormone and follicle-stimulating hormone, and then stimulates follicle growth. After the follicle matures, the release of estrogen increases, and the release of preovulatory gonadotropin is stimulated by positive feedback to reach a peak, so ovulation occurs. The treatment of male infertility may be related to the increase of FSH and LH and the promotion of sperm production.
[Storage] Keep away from light and sealed.
[Specification] 50mg
[Packaging specification] 50mg*20s/box
[Validity period] 24 months
[Approval number] National Medicine Standard H44021970
[Manufacturer] Company name: Guangzhou Kanghe Pharmaceutical Co., Ltd.
