Product Overview
[Drug Name]
Generic Name: Amlodipine Besylate Tablets
Trade Name: Jiujingtang Amlodipine Besylate Tablets 5mg*45 Tablets
Pinyin Code: JiuJingTang BenHuangSuanAnLvDiPingPian 5mg*45 Tablets
[Main Ingredients]
The main ingredient of this product is amlodipine besylate. Chemical Name: 3-Ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate benzenesulfonate. Molecular Formula: C20H25N2O5Cl·C6H6O3S. Molecular Weight: 567.06
[Properties]
This product is white tablets.
[Indications/Main Functions]
1. Hypertension: This product is indicated for the treatment of hypertension. It can be used alone or in combination with other antihypertensive drugs. 2. Coronary Artery Disease (CAD): Chronic stable angina. This product is indicated for the symptomatic treatment of chronic stable angina. It can be used alone or in combination with other anti-anginal drugs. Vasospastic angina (Prinzmetal's or variant angina). This product is indicated for the treatment of confirmed or suspected vasospastic angina. It can be used alone or in combination with other anti-anginal drugs.
[Precautions]
1. Warning: A very small number of patients, especially those with severe coronary artery obstructive disease, may experience increased frequency, prolonged duration, and/or severity of angina, or acute myocardial infarction, when initiating or increasing the dose of calcium channel blockers. The mechanism of action is currently unknown. 2. Because the vasodilatory effect of this product is gradual, rare cases of acute hypotension have been reported after taking this product. However, caution should be exercised when using this product in combination with other peripheral vasodilators in patients with severe aortic stenosis. 3. Use in Patients with Heart Failure: Calcium channel blockers should be used with caution in patients with congestive heart failure. In a long-term, placebo-controlled study (PRAISE-2) in patients with non-ischemic heart failure (NYHA class III-IV), although the incidence of exacerbations of heart failure did not differ significantly from placebo, there was an increase in reports of amlodipine-related pulmonary edema. 4. Use in Patients with Impaired Hepatic Function: As with all other calcium channel blockers, the half-life of this drug is prolonged in patients with impaired hepatic function, but a recommended dose for this drug in such patients has not yet been established. Therefore, this drug should be used with caution in such patients. 5. Use in Patients with Renal Failure: Changes in amlodipine plasma concentrations are not correlated with the degree of renal impairment; therefore, a normal dose can be used. This drug cannot be dialyzed. 6. Discontinuation of Beta-Blockers: Amlodipine is not a beta-blocker and therefore offers no protection against the risks associated with abrupt discontinuation of beta-blockers; any beta-blocker should be discontinued gradually.
[Drug Interactions]
This drug is contraindicated in patients with hypersensitivity to dihydropyridines or any of the ingredients in this drug.
[Specifications]
5mg*45 tablets
[Dosage and Administration]
Adults: The typical starting dose for hypertension is 5 mg once daily, with a maximum dose of 10 mg once daily. For patients who are small, frail, elderly, or have hepatic insufficiency, the starting dose is 2.5 mg once daily. This dose may also be used in combination with other antihypertensive medications. Dose adjustments should be made based on individual patient response. Generally, dose adjustments should be initiated 7-14 days after administration. If clinically necessary, dose adjustments may be made more quickly under close patient monitoring. The recommended dose for the treatment of chronic stable or vasospastic angina is 5-10 mg once daily. Lower doses are recommended for elderly patients and those with hepatic insufficiency. The effective dose for most patients is 10 mg once daily. The recommended dose for the treatment of coronary artery disease is 5-10 mg once daily. In clinical studies, most patients required a dose of 10 mg/day. Combination with other antihypertensive and/or antianginal medications: Amlodipine is safe to use with thiazide diuretics, angiotensin-converting enzyme inhibitors, beta-blockers, long-acting nitrates, and/or sublingual nitroglycerin.
[Adverse Reactions]
See package insert for details.
[Contraindications]
This product is contraindicated in patients with hypersensitivity to dihydropyridines or any of its ingredients.
