Product Overview
【Drug name】
Generic name: Shuangzuotai suppository
Trade name: Guodi Shuangzuotai suppository 7 pieces
Pinyin full code: GuoDi Shuangzuotai suppository 7Mei
【Main ingredients】
This product is a compound preparation, each tablet contains the main ingredients of metronidazole 200 mg, clotrimazole 160 mg, and chlorhexidine acetate 8 mg. The excipients are semi-synthetic fatty acid glycerides, lanolin, and paraffin.
【Properties】
This product is a white to milky yellow suppository.
【Indications/Main functions】
It is used for bacterial vaginitis, candidal vulvovaginal and trichomonal vaginitis, as well as mixed bacterial, fungal, and trichomonal infection vaginitis.
【Specifications】
7 pieces (Guodi)
【Usage and dosage】
For vaginal administration, wash your hands before going to bed, take the suppository, remove the outer packaging, put on a fingertip, and insert this product into the deep part of the vagina (posterior fornix), 1 tablet each time, and use it for 7 consecutive days as a course of treatment. Repeat the course of treatment after the first menstrual period after stopping the drug.
【Adverse Reactions】
Occasionally, skin rash, vaginal burning sensation, itching or other mucosal irritation symptoms may occur. Because this product can be absorbed from the mucosa, long-term and large-scale use may also produce the same adverse reactions as systemic medication:
1. It can cause epileptic seizures and peripheral neuropathy, the latter of which is mainly manifested as numbness and paresthesia of the extremities. In some cases, long-term use of the drug may cause persistent peripheral neuropathy.
2. Other common adverse reactions include:
(1) Gastrointestinal reactions, such as nausea, loss of appetite, vomiting, diarrhea, abdominal discomfort, taste changes, dry mouth, metallic taste in the mouth, etc.
(2) Reversible neutropenia.
(3) Allergic reactions, skin rash, urticaria, itching, etc.
(4) Central nervous system symptoms, such as headache, dizziness, syncope, paresthesia, limb numbness, ataxia and mental confusion, etc.
(5) Other symptoms include elevated serum aminotransferase, fever, cystitis, dysuria, dark urine, etc., which are all reversible and will recover on their own after stopping the medication.
【Contraindications]
1. Patients who are allergic to pyrrole (imidazole) drugs are contraindicated.
2. Patients with active central nervous system diseases and blood diseases are contraindicated.
3. Pregnant women are contraindicated.
【Precautions】
1. This product is only for vaginal administration and should not be taken orally.
2. Avoid using this product during menstruation.
3. Women with no sexual history should use this product under the guidance of a physician.
4. If there is a burning sensation, redness or swelling at the medication site, stop taking the medication and wash off the local medication. Consult a physician if necessary.
5. Wash your hands or wear cots or gloves when administering the medication.
6. Pay attention to personal hygiene during medication to prevent repeated infection, use condoms or avoid sexual intercourse.
7. Lactating women should stop breastfeeding when using this product.
8. Elderly people should use this product with caution.
9. If allergic symptoms or adverse reactions of the central nervous system occur during use, the drug should be discontinued immediately.
10. Use with caution in patients with impaired liver and kidney function.
11. When treating vaginal trichomoniasis, the sexual partner must be treated at the same time.
12. Do not drink alcohol or beverages containing alcohol during the use of this product.
13. It is forbidden for those who are allergic to this product, and it should be used with caution by those with allergic constitution.
14. It is forbidden to use this product when its properties change.
15. Please keep this product out of reach of children.
16. If you are using other drugs, please consult a doctor or pharmacist before using this product.
【Drug Interactions】
1. Chlorhexidine is incompatible with soap, potassium iodide, etc. It is also incompatible with borax, bicarbonate, carbonate, oxide, citrate, phosphate and sulfate. 2. When this product is used in combination with oxytetracycline, the latter may interfere with the effect of metronidazole in removing vaginal trichomoniasis. 3. Long-term and large-scale use, after absorption through the mucosa, may also produce drug interactions similar to systemic medication, such as inhibiting the metabolism of warfarin and other oral anticoagulants, interfering with disulfiram metabolism and serum aminotransferase and lactate dehydrogenase assay results, and combining with liver microsomal enzyme inducers or inhibitors to accelerate or slow down the metabolism of this product in the liver. 4. If used with other drugs at the same time, drug interactions may occur. Please consult a physician or pharmacist for details.
【Pharmacology and Toxicology】
The metronidazole contained in this product is an anti-anaerobic and anti-trichomonal drug; clotrimazole is a broad-spectrum antifungal drug that has antibacterial effects on a variety of superficial and deep fungi. Its mechanism of action is to inhibit the synthesis of fungal cell membranes and affect their metabolic processes; chlorhexidine acetate is a quaternary ammonium salt cationic surfactant that has a bactericidal effect on Gram-positive bacteria. The combination of the three drugs has a synergistic effect, which is not only suitable for simple fungal, bacterial or trichomonal infections, but also for mixed infections.
【Storage】
Light-shielded and sealed, below 30℃
【Packaging】
Double-layer PE pressed packaging; 7 pieces/box (7 medical plastic finger cots inside).
【Validity period】
24 months
【Approval number】
National Medicine Standard H10983147
【Manufacturer】
Huludao Guodi Pharmaceutical Co., Ltd.
