Product Overview
[Drug name]
Generic name: Tamsulosin hydrochloride sustained-release capsules
Trade name: Hengrui Tamsulosin hydrochloride sustained-release capsules 0.2mg*10 capsules
Pinyin full code: HengRui YanSuanTanSuoLuoXinHuanShiJiaoNang 0.2mg*10Li
[Main ingredients]
The main ingredient is tamsulosin hydrochloride.
[Properties]
This product is a capsule containing off-white particles.
[Indications/Main Functions]
Urinary disorders caused by prostatic hyperplasia.
[Specifications]
0.2mg*10 tablets
[Usage and Dosage]
Oral, adults once a day, 1 or 2 tablets each time, can be adjusted appropriately according to age and symptoms.
[Adverse Reactions]
1. Neuropsychiatric system: dizziness, staggering, etc. are occasionally seen. 2. Circulatory system: blood pressure drop, heart rate increase, etc. are occasionally seen. 3. Allergic reaction: skin rash may occur occasionally, and the drug should be stopped when such symptoms occur. 4. Digestive system: nausea, vomiting, stomach discomfort, abdominal pain, loss of appetite, etc. are occasionally seen. 5. Liver function: ALT, AST, and LDH are occasionally elevated, and they return to normal after stopping the drug. 6. Others: nasal congestion, edema, difficulty swallowing, fatigue, etc. are occasionally seen.
[Contraindications]
1. It is contraindicated for those who are allergic to this drug. 2. It is contraindicated for patients with renal insufficiency.
[Drug Interactions]
When taking antihypertensive drugs together, pay close attention to changes in blood pressure.
[Precautions]
1. Be careful not to chew it before taking it, but swallow it whole. 2. Patients with postural hypotension and coronary heart disease should use it with caution. 3. Patients with renal insufficiency should use it with caution or prohibit it depending on the Ccr situation.
[Drug Use in Children]
This experiment has not been conducted and there are no reliable references.
[Drug Use in Elderly Patients]
Because elderly patients often have low renal function, in this case, full attention should be paid to observing the patient's condition after taking the medicine. If the expected effect is not achieved, the dosage should not be increased, but other appropriate treatment methods should be used instead.
[Pharmacology and Toxicology]
Pharmacological effects: 1. Blocking effect on sympathetic nerve α1 receptors (refer to the instructions for use of Harle?) This product can selectively block α1 receptors, and its effect is 0.5-22 times stronger than prazosin hydrochloride and 45-140 times stronger than phentolamine mesylate. In addition, the affinity of this product for α1 receptors is 5400-24000 times stronger than its α2 receptor counterpart. 2. Effects on the urethra, bladder and prostate Because this product is a specific antagonist of the α1 receptor subtype α1A, and the α1 receptors present in the urethra, bladder neck and prostate are mainly α1A receptors, this product has a highly selective blocking effect on the urethra, bladder neck and prostate smooth muscle, relaxes the smooth muscle, reduces urethral compression, and its ability to inhibit the increase in urethral pressure is 13 times that of inhibiting the increase in vasodilation pressure. 3. Effect of improving urination disorders This product can reduce the prostate pressure in the urethral pressure curve, but has no effect on rhythmic bladder contraction and bladder pressure curve. Toxicological studies? : According to literature reports 1. Subacute toxicity test: After continuous administration of tamsulosin hydrochloride to rats and beagles (□) for 3 months, the weight of the uterus and ovaries was found to be reduced. 2. Carcinogenic toxicity: After female mice took tamsulosin hydrochloride 45mg/Kg/d and 158mg/Kg/d for 2 years, the incidence of breast fibroadenoma (p<0.001) and adenocarcinoma (P>0.075) increased. The occurrence of breast cancer in female rats and mice in the test may be related to the increase in prolactin caused by tamsulosin hydrochloride. 3. Teratogenic toxicity: In various known tests, tamsulosin hydrochloride has been proven to have no teratogenic effect. 4. Reproductive toxicity: Single or multiple doses of tamsulosin hydrochloride 300 mg/Kg/d in male rats can lead to a significant decline in reproductive function, but this effect is reversible. Reproductive function improves after stopping the single dose for 3 days or the multiple dose for 4 weeks, and returns to normal after stopping the multiple dose for 9 weeks. Multiple doses of 10 mg/Kg/d or 100 mg/Kg/d in male rats (the AUC area under the curve is 0
and 16 times that of normal people, respectively) will not affect reproductive function.
