Product Overview
[Drug name]
Generic name: Indapamide Tablets
Trade name: Hezhi
English name: Indapamide Tablets
Chinese Pinyin: Yindapa An Pian
[Ingredients]
The main ingredient and chemical name of this product is indapamide, and its chemical name is N-(2-methyl-2,3-dihydro-1H-indolyl)-3-sulfamoyl-4-chloro-benzamide. Molecular formula: C16H16CIN3O3S Molecular weight: 365.83
[Properties]
This product is a film-coated tablet; it appears white after removing the film coating.
[Indications]
For the treatment of hypertension.
[Usage and Dosage]
Common dosage for adults. Oral, 2.5 mg (1 tablet) once a day.
[Adverse reactions]
Relatively mild and short-lived, dose-related. 1. Less common are: diarrhea, headache, loss of appetite, insomnia, nausea, orthostatic hypotension. 2. Rare symptoms include: allergic reactions such as rash and itching; hyponatremia, hypokalemia, and hypochloremic alkalosis.
[Contraindications]
Allergic to sulfonamides, severe renal insufficiency, hepatic encephalopathy or severe liver insufficiency, hypokalemia.
[Precautions]
1. In order to reduce the possibility of electrolyte imbalance, a smaller effective dose should be used, and blood potassium, sodium and uric acid should be monitored regularly, and attention should be paid to maintaining water and electrolyte balance, and potassium should be supplemented in time. 2. When used as a diuretic, it is best to give the drug once a morning to avoid getting up to urinate at night. 3. Anuria or severe renal insufficiency can induce azotemia. 4. Glucose tolerance can be worse in diabetes. 5. Gout or hyperuricemia, at this time, blood uric acid can be further increased. 6. Liver insufficiency, diuresis can induce hepatic coma. 7. After sympathectomy, the antihypertensive effect will be enhanced at this time. 8. If surgery is required after using this product, it is not necessary to stop using this product, but the anesthesiologist must be informed. 9. Athletes should use with caution.
[Use in special populations]
Children's precautions: Not yet clear.
Precautions during pregnancy and lactation: There is no human study on the effect on pregnancy, and no problems have been found in animal studies. It is not clear whether indapamide tablets are excreted into breast milk, but no problems have occurred in human use.
Precautions for the elderly: The elderly are more sensitive to antihypertensive effects and electrolyte changes, and often have changes in renal function. Caution should be taken when using indapamide tablets.
[Drug Interactions]
1. The diuretic and natriuretic effects of this product are weakened when used with adrenal cortical hormones; 2. When used with amiodarone, it is easy to cause arrhythmia due to low blood potassium; 3. The anticoagulant effect of this product is weakened when used with oral anticoagulants; 4. The natriuretic effect of this product is weakened when used with non-steroidal anti-inflammatory analgesics; 5. The diuretic effect of this product is enhanced when used with dopamine; 6. The antihypertensive effect of this product is enhanced when used with other types of antihypertensive drugs; 7. The antihypertensive effect of this product is weakened when used with sympathomimetics; 8. When used with lithium, this product can increase blood lithium concentration and show signs of overdose; 9. When used with large doses of salicylates, dehydrated patients may develop acute renal failure; 10. Lactic acidosis is prone to occur when used with metformin.
[Pharmacological Actions]
It is a sulfonamide diuretic that works by inhibiting the reabsorption of water and electrolytes in the dilution segment of the distal renal tubular cortex. The antihypertensive mechanism is unknown, and its diuretic effect cannot explain the antihypertensive effect, because the dose of antihypertensive effect is much lower than the dose of diuretic effect. Possible mechanisms include the following aspects: regulating calcium influx in vascular smooth muscle cells; stimulating the synthesis of prostaglandins PGE2 and prostaglandins PGI2; reducing the hypersensitivity of blood vessels to vasopressor amines, thereby inhibiting vasoconstriction. This product has little or no effect on cardiac output, heart rate and rhythm when lowering blood pressure. Long-term use of this product rarely affects glomerular filtration rate or renal blood flow. This drug does not affect the metabolism of blood lipids and carbohydrates. (A group of biologically active substances derived from twenty-carbon unsaturated fatty acids containing a five-membered ring. According to the position of double bonds, number or hydroxyl position, the presence or absence of endoperoxide structure, etc., it is divided into nine categories from PGA to PGI. It has the effects of lowering blood pressure, smooth muscle contraction, regulating inflammatory response, promoting blood coagulation, immune response and counteracting other hormones.)
[Storage]
Shaded and sealed.
[Specification] 2.5 mg
[Packaging specification]
2.5 mg*30s*1 box
[Validity period] 24 months.
[Approval number] National Medicine Standard H20056713
[Manufacturer] Company name: Tianjin Hezhi Pharmaceutical Co., Ltd.
