Product Overview
[Drug Name]
Generic Name: Ambroxol Hydrochloride Dispersible Tablets
Trade Name: Bi Yu
English Name: Ambroxol Hydrochloride Dispersible Tablets
Chinese Pinyin: Yansuan Anxiusuo Fensan Pian
[Ingredients]
trans-4-[(2-amino-3,5-dibromophenyl)methyl-amino]-cyclohexanol hydrochloride
[Properties]
This product is white or off-white tablets.
[Indications]
It is suitable for patients with thick and difficult sputum.
[Dosage and Administration]
Oral: 1. Adults: 30 mg three times a day. Long-term use can be reduced to twice a day. 2. Children: Children over 12 years of age should take the same dose as adults. Children under 12 years of age are recommended to take 1.2-1.6 mg per kilogram of body weight per day.
[Adverse Reactions]
Allergic reactions are rare, primarily rash.
[Contraindications]
This product is contraindicated in patients with allergies.
[Precautions]
1. Use with caution in pregnant and lactating women. 2. Consult a physician or pharmacist regarding dosage for children. 3. Avoid concomitant use with centrally acting antitussives (such as dextromethorphan) to prevent airway obstruction caused by thinned sputum. 4. This product is a mucus regulator and is only effective for expectoration. When using this product, pay attention to the cause of the cough and expectoration. If no improvement occurs after 7 days of use, seek medical attention immediately. 5. In case of overdose or severe adverse reactions, seek medical attention immediately. 6. Contraindicated for those allergic to this product. Use with caution if allergic. 7. Do not use if the product's properties change. 8. Keep out of reach of children. 9. Children must be supervised by an adult before use. 10. If you are using other medications, consult a physician or pharmacist before using this product.
[Use in Special Populations]
Precautions for Children: Not yet available.
Precautions for Pregnancy and Lactation: Not yet available.
Precautions for the Elderly: Not yet available.
[Drug Interactions]
1. Taking this product with antibiotics (amoxicillin, cefuroxime, erythromycin, doxycycline) may increase the concentration of antibiotics in lung tissue. 2. If you are taking other medications, consult your physician or pharmacist before using this product.
[Pharmacological Actions]
(1) Stimulates bronchial mucous glands, increasing the secretion of neutral mucopolysaccharides, reducing the synthesis and metabolism of acidic mucopolysaccharides, thereby normalizing the physical and chemical properties of respiratory mucus and facilitating its excretion.
(2) Stimulates alveolar epithelial cells and Clara cells, promoting the synthesis and secretion of alveolar surfactant. Activates pneumocytes to synthesize surfactant, which coats the entire respiratory epithelium and directly protects lung function. Increases phosphatidylcholine content in alveolar macrophages, affecting phospholipid metabolism in the lungs, whereas cysteine mucolytics do not have this effect. This product also promotes the synthesis and secretion of gastric surfactant.
(3) Activates the ciliary function of the respiratory mucosa, reducing the adhesion of sputum to cilia and increasing ciliary movement frequency by 10.8%, facilitating the excretion of respiratory secretions. This product also has the effect of increasing antibiotic concentrations in lung tissue and its secretions.
(4) Anti-inflammatory and antioxidant properties: In vitro studies have shown that ambroxol reduces the secretion of cytokines IL-1, TNF-a, and IF-γ by activated alveolar cells in bronchopulmonary lavage fluid and peripheral blood mononuclear cells; inhibits the production of IL-1 and TNF by human monocytes in vitro; and significantly inhibits the release of inflammatory mediators such as arachidonic acid oxidation products caused by ozone-induced airway hyperresponsiveness. Ambroxol can protect against peroxide-induced lung damage, including asthma, and enhance the antioxidant activity of lung tissue, making it an effective anti-lipid peroxidation agent.
[Storage]
Store in sealed containers.
[Strength]
30 mg
[Packaging Specifications]
30 mg x 30 seconds/box
[Expiry Date]
36 months
[Approval Number]
National Medicine Standard H20060369
[Manufacturer]
Company Name: Tongliao Huabang Pharmaceutical Co., Ltd.
