Product Overview
[Drug Name]
Generic Name: Valsartan Capsules
Trade Name: China Resources Saike Pharmaceuticals/Suiyue
English Name: Valsartan Capsules
Chinese Pinyin: Xiashatan Jiaonang
[Ingredients]
Valsartan.
[Properties]
This product is a capsule containing white granules or powder.
[Indications]
It is suitable for all types of mild to moderate hypertension, especially for patients intolerant to ACE inhibitors.
[Dosage and Administration]
Oral administration: one capsule once daily.
[Adverse Reactions]
Adverse reactions are rare, mild, and transient: 1. Mild headache, dizziness, fatigue, abdominal pain, dry cough, and postural blood pressure changes may occur occasionally. 2. Increased serum potassium, neutropenia, decreased hemoglobin and hematocrit, and increased serum creatinine and transaminases may occur occasionally. 3. Adverse reactions such as diarrhea, rhinitis, pharyngitis, arthralgia, and nausea have been reported.
[Contraindications]
This product is contraindicated in patients with allergies. Contraindicated for pregnant women.
[Precautions]
1. Patients with abnormal blood volume and electrolytes should be careful to prevent hypotension. 2. Use with caution in lactating women. 3. Use with caution in patients with severe hepatic or renal impairment.
[Special Population Use]
Precautions for Children:
The efficacy and safety of this drug in children and adolescents (under 18 years of age) have not been studied.
Precautions for Pregnancy and Lactation:
Contraindicated for pregnant women.
Precautions for the Elderly:
Although systemic exposure to valsartan in the elderly is slightly higher than in younger adults, this effect is not clinically significant.
[Drug Interactions]
This drug has no significant interactions with amlodipine, atenolol, cimetidine, digoxin, furosemide, glyburide, hydrochlorothiazide, or indomethacin. The combined antihypertensive effect of this drug with atenolol is greater than either alone, but it does not further reduce heart rate compared to atenolol alone. This drug's pharmacokinetics are not altered when used in combination with warfarin, nor does it affect the anticoagulant effect of warfarin. However, concomitant use with potassium-sparing diuretics, potassium preparations, or potassium-containing salt substitutes may increase serum potassium.
[Pharmacological Action]
This drug is an angiotensin II receptor antagonist. It selectively targets the AT1 receptor subtype, known to be involved in the action of angiotensin II, selectively blocking the binding of angiotensin II to AT1 receptors on tissues such as the adrenal glands and vascular smooth muscle, inhibiting vasoconstriction and aldosterone secretion, resulting in a hypotensive effect. Its affinity for AT1 receptors is approximately 20,000-fold higher than for AT2 receptors. This drug does not affect the action of bradykinin or ion channel function, nor does it bind to the receptors of other hormones that play an important role in regulating cardiovascular function. This product is not carcinogenic, teratogenic, or mutagenic, and has no reproductive toxicity.
[Storage] Sealed
[Specification] 80mg x 24 capsules
[Packaging] Box
[Expiry Date] 36 months
Approval Number: National Medicine Standard H20030638
Manufacturer: China Resources Secco Pharmaceuticals Co., Ltd.
