Product Overview
[Drug Name]
Generic Name: Compound Hypotensive Tablets
Trade Name: Shuanghe Pharmaceutical/No. 0
English Name: Compound Hypotensive Tablets
Chinese Pinyin: Fufang Lixueping Anbendieding Tablets
[Ingredients]
This product is a compound preparation. Each tablet contains 125mg of hydrochloride, 12.5mg of hydralazine sulfate, and 0.1mg of reserpine.
[Properties]
This product is a film-coated tablet. It appears yellow after removing the film coating.
[Indications]
For the treatment of mild to moderate hypertension. For severe hypertension, it should be used in combination with other antihypertensive drugs.
[Dosage and Administration]
Oral. Usual dose: 1 tablet once daily. Maintenance dose: 1 tablet once every two to three days.
[Adverse Reactions]
Occasionally may cause dizziness, headache, fatigue, nasal congestion, and drowsiness. These symptoms disappear with dosage reduction or discontinuation.
[Contraindications]
1. Do not use if allergic to this product. 2. Contraindicated in patients with active ulcerative colitis, ulcerative colitis, depression, or severe renal dysfunction.
[Precautions]
Use with caution in the following situations: 1. Patients with gastric or duodenal ulcers; 2. Patients with hyperuricemia or a history of gout; 3. Patients with arrhythmias or a history of myocardial infarction; 4. Athletes.
[Special Population Use]
Precautions for Children:
No data are available for use in children.
Precautions for Pregnancy and Lactation:
Contraindicated.
Precautions for Elderly:
Elderly patients have a certain degree of physiological decline in renal function; therefore, the dosage should be reduced under the guidance of a physician.
[Drug Interactions]
This study has not been conducted and no reliable references are available.
[Pharmacological Actions]
Hydrochlorothiazide and triamterene are diuretics that reduce water and sodium retention, decrease blood volume, and reduce circulating blood volume, thereby lowering blood pressure. At the same time, because sodium excretion reduces sodium ion concentration in the blood vessel wall, it weakens vascular responsiveness to catecholamines and angiotensin, thereby enhancing the antihypertensive effect of baseline antihypertensive medications and creating a synergistic effect. The combined use of hydrochlorothiazide and triamterene can enhance diuresis, reduce the dosage of each medication, and antagonize each other's side effects. Hydrochlorothiazide acts on the distal convoluted tubule and the cortical portion of the ascending limb of the loop of Henle, inhibiting sodium ion reabsorption, allowing a larger amount of sodium ions to reach the distal convoluted tubule and collecting duct, resulting in a diuretic effect. Triamterene is a potassium-sparing diuretic with a weaker diuretic effect and can alleviate hydrochlorothiazide-induced hypokalemia. Hydralazine sulfate and reserpine are antihypertensive drugs that dilate arterioles and lower blood pressure. Reserpine can reduce or even deplete the amount of the conduction mediator norepinephrine stored in sympathetic postganglionic fiber terminals, resulting in an inhibitory effect on noradrenergic nerves and a lowering of blood pressure. The combined use of these two drugs has a synergistic antihypertensive effect.
[Storage] Store in a dark, airtight container.
[Specification] 10 tablets
[Packaging] Box
[Expiration Period] 24 months
[Approval Number] National Medicine Standard H11022335
[Manufacturer] China Resources Double-Crane Pharmaceutical Co., Ltd.
