Product Overview
[Drug Name]
Generic Name: Domperidone Dispersible Tablets
Trade Name: Huiren Domperidone Dispersible Tablets, 10mg x 30 tablets/box
Pinyin Full Code: HuiRen DuoPanLiTongFenSanPian
[Main Ingredients]
Each tablet contains 10mg of domperidone. Excipients include: starch, microcrystalline cellulose, lactose, sodium starch glycolate, aspartame, and magnesium stearate.
[Properties]
This product is a white tablet.
[Indications/Main Functions]
Indigestion, abdominal distension, belching, nausea, vomiting, and abdominal pain.
[Specifications]
10mg x 30 tablets/box
[Dosage and Administration]
Oral. Adults: 1 tablet three times daily, 15-30 minutes before meals.
[Adverse Reactions]
1. Mild abdominal cramps, dry mouth, rash, headache, diarrhea, nervousness, fatigue, drowsiness, and dizziness may occasionally occur.
2. Occasionally, elevated serum prolactin levels, galactorrhea, and gynecomastia may occur, but these symptoms return to normal after discontinuation of the drug.
[Contraindications]
This product is contraindicated in patients with pheochromocytoma, breast cancer, mechanical intestinal obstruction, or gastrointestinal bleeding.
[Precautions]
1. Use with caution in pregnant women. Breastfeeding women should discontinue breastfeeding while using this product.
2. Domperidone suspension is recommended for children.
3. Caution is advised in patients with heart disease (arrhythmias) and cancer patients undergoing chemotherapy, as this product may aggravate heart rhythm disorders.
4. In case of overdose or serious adverse reactions, seek medical attention immediately.
5. This product is contraindicated in patients with allergies and should be used with caution in those with allergic constitutions.
6. This product should not be used if its properties change. 7. Keep this product out of reach of children.
8. If you are taking other medications, consult your physician or pharmacist before using this product.
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[Drug Interactions]
1. Do not use with azole antifungals such as ketoconazole and itraconazole, macrolide antibiotics such as erythromycin, HIV protease inhibitors, and nefazodone. 2. Anticholinergic drugs such as tacrolimus, propantheline bromide, anisodamine, and belladonna tablets can weaken the effects of this product and should not be taken with it. 3. Antacids and drugs that inhibit gastric acid secretion can reduce the bioavailability of this product and should not be taken with this product. 4. Concomitant use of this product with digoxin may reduce the absorption of digoxin. 5. Concomitant use with other medications may cause drug interactions. Please consult your physician or pharmacist for details.
[Use in Children]
Due to the immature development of the blood-cerebrospinal fluid barrier in children under one year of age, the possibility of central nervous system side effects cannot be ruled out.
[Use in Elderly Patients]
Use in elderly patients is the same as for adults. However, liver and kidney function declines with age. Therefore, use under the guidance of an experienced physician.
[Use in Pregnant and Lactating Women]
Animal studies have shown that domperidone can cause skeletal and visceral malformations in rats and is secreted in rat milk. Therefore, pregnant women and women of childbearing potential should avoid this drug, and breastfeeding women should use it with caution.
[Overdose]
Symptoms of overdose include drowsiness, disorientation, and extrapyramidal effects. In the event of an overdose, administration of activated charcoal and close observation are recommended.
[Pharmacology and Toxicology]
This drug acts directly on the gastrointestinal wall, increasing gastrointestinal motility and tonicity, promoting gastric emptying, increasing antral and duodenal motility, and coordinating pyloric contractions. It also enhances esophageal motility and lower esophageal sphincter tone, suppressing nausea and vomiting. It does not readily cross the blood-brain barrier.
[Pharmacokinetics]
After oral administration, this drug is rapidly absorbed, reaching peak plasma concentrations within 15-30 minutes. Distribution is highest in the gastrointestinal tract, followed by plasma, with virtually no concentration in the brain. This drug is almost entirely metabolized in the liver. The half-life is 7 hours. Urinary excretion accounts for 31.23%, with unchanged drug accounting for 0.4%. Fecal excretion accounts for 65.7%, with unchanged drug accounting for 10%.
[Storage]
Sealed.
[Expiry Period]
24 months
[Approval Number]
National Medicine Standard H20031268
[Manufacturer]
Jiangxi Huiren Pharmaceutical Co., Ltd.
