Product Overview
[Drug Name]
Generic Name: Probucol Tablets
Trade Name: Changtai
English Name: Probucol Tablets
Chinese Pinyin: Puluobukao Pian
[Ingredients]
The main ingredient of this drug is probucol. Its chemical name is 4,4-[(1-methylethylidene)dibis]2,6-bis(1,1-dimethylethyl)phenol. Subformula: C₁₃H₄₁₈O₂S₂. Molecular Weight: 516.85
[Properties]
This product is a white or off-white tablet.
[Indications]
For the treatment of hypercholesterolemia.
[Dosage and Administration]
The usual adult dose is 0.5g twice daily, taken with breakfast and dinner.
[Adverse Reactions]
The most common adverse reaction to this drug is gastrointestinal discomfort, with diarrhea occurring in approximately 10% of patients. Other side effects include flatulence, abdominal pain, nausea, and vomiting. 2. Other rare reactions include: headache, dizziness, paresthesia, insomnia, tinnitus, rash, and itchy skin. 3. Allergic reactions such as angioedema have been reported. 4. Rare and serious adverse reactions include: QT interval prolongation on the electrocardiogram (ECG), ventricular tachycardia, and thrombocytopenia.
[Contraindications]
1. This product is contraindicated in patients allergic to probucol. 2. This product may cause QT interval prolongation on the ECG and severe ventricular arrhythmias. Therefore, it should be avoided in the following situations: ① Recent myocardial damage, such as a recent myocardial infarction; ② Severe ventricular arrhythmias, such as bradycardia; ③ Cardiac syncope or unexplained syncope; ④ QT interval prolongation; ⑤ Current reactions to medications that prolong the QT interval; ⑥ Low serum potassium or magnesium levels.
[Precautions]
1. This product may interfere with diagnosis: it may cause transient increases in serum aminotransferases, bilirubin, creatine phosphokinase, uric acid, and urea nitrogen. 2. The QT interval should be checked regularly during electrocardiogram (ECG) use. 3. Patients taking tricyclic antidepressants, class I and class III antiarrhythmic drugs, and phenothiazines are at increased risk of arrhythmias when taking this product.
[Special Population Use]
Precautions for Children:
The safety of this product in children is unknown; therefore, it should not be used.
Precautions for Pregnancy and Lactation:
The safety of this product during pregnancy is unknown, and whether it is excreted into breast milk is unknown. Therefore, it is not recommended for use in pregnant and lactating women.
Precautions for Elderly:
The dose of this product should be reduced in patients with impaired renal function. This product is more effective in lowering cholesterol and LDL cholesterol in patients over 65 years of age than in younger patients.
[Drug Interactions]
1. When this product is used in combination with drugs that may cause arrhythmias, such as tricyclic antidepressants, class I and class III antiarrhythmic drugs, and phenothiazines, the risk of adverse reactions should be considered increased. 2. This product may enhance the anticoagulant effect of coumarins. 3. This product may enhance the effects of hypoglycemic drugs. 4. When used in combination with cyclosporine, this product may significantly reduce the blood concentration of cyclosporine compared to cyclosporine alone.
[Pharmacological Actions]
This product is a lipid-regulating drug with anti-atherosclerotic properties. Its lipid-lowering effects are achieved by reducing cholesterol synthesis and promoting cholesterol breakdown, thereby lowering blood cholesterol and low-density lipoprotein cholesterol. It also alters the properties and function of high-density lipoprotein subtypes, thereby reducing blood high-density lipoprotein cholesterol. The clinical significance of its HDL cholesterol-lowering effects is unknown. This product has minimal effect on blood triglycerides. It has significant antioxidant properties, inhibiting the formation of foam cells, delaying the formation of atherosclerotic plaques, and regressing established atherosclerotic plaques. Existing studies have not found this product to be carcinogenic or mutagenic.
Storage: Store in a dark, airtight, dry place.
Specifications: 0.25g x 24 tablets
Expiry Period: 36 months.
Approval Number: National Medicine Standard H10960161
Manufacturer: Jingfukang Pharmaceutical Group Co., Ltd.
