Product Overview
[Drug Name]
Generic Name: Compound Glycyrrhizin Tablets
Trade Name: Shuai Neng
English Name: Compound Glycyrrhizin Tablets
Chinese Pinyin: Fufang Gancaosuangan Pian
[Ingredients]
This product is a compound preparation. Each tablet contains 25 mg of glycyrrhizin (25.52 mg as monoammonium glycyrrhizate), 25 mg of glycine, and 25 mg of methionine.
[Properties]
This product is an off-white sugar-coated tablet. After removing the coating, it appears white or off-white.
[Indications]
Treats chronic liver disease and improves liver function. It can also be used to treat eczema, dermatitis, and alopecia areata.
[Dosage and Administration]
Adults generally take 2-3 tablets at a time; children take 1 tablet three times daily after meals. The dosage may be increased or decreased based on age and symptoms.
[Adverse Reactions]
The actual frequency of adverse reactions associated with the use of this product has not been investigated. Significant Adverse Reactions: Pseudoaldosteronism (frequency unknown): Symptoms of pseudoaldosteronism, such as hypokalemia, increased blood pressure, sodium and fluid retention, edema, decreased urine volume, and weight gain, may occur. Therefore, during medication, carefully monitor serum potassium levels and discontinue medication if abnormalities are detected. Symptoms of rhabdomyolysis, such as weakness, muscle weakness, muscle pain, limb cramps, and paralysis, may also occur. If elevated CK (CPK) levels or elevated blood or urine myoglobin are detected, discontinue the drug and administer appropriate treatment.
[Contraindications]
(The following patients should not receive this medication): 1. Patients with aldosteronism, myopathy, or hypokalemia (it may worsen hypokalemia and hypertension). 2. Patients with advanced cirrhosis who are prone to elevated blood ammonia levels (methionine metabolites in this preparation can inhibit urea synthesis, thereby reducing ammonia processing capacity).
[Precautions]
1. Use with caution: Use with caution in elderly patients (elderly patients have a higher incidence of hypokalemia) (refer to medication for elderly patients).
2. General Precautions: Because this preparation contains glycyrrhizin, concomitant use with other licorice-containing preparations may increase glycyrrhizin levels in the body, potentially leading to pseudoaldosteronism. Caution should be exercised.
[Use in Special Populations]
Precautions for Children:
For children, take one tablet three times daily after meals.
Precautions for Pregnancy and Lactation:
Pregnant and lactating women should use this medication with caution after weighing the benefits against the risks.
Precautions for the Elderly:
Based on clinical experience, the elderly are more susceptible to adverse reactions such as hypokalemia. Therefore, use with caution under close observation.
[Drug Interactions]
Caution should be exercised when using combined medications.
[Pharmacological Actions]
1. Anti-inflammatory Effects
1.1. Anti-allergic Effects: Glycyrrhizic acid glycoside has anti-allergic effects, including inhibiting local allergic necrosis (Arthus Phenomenon) and Schwartzman Phenomenon in rabbits. It potentiates the stress-inhibiting effects of corticosteroids and antagonizes their anti-granulation and thymic atrophy effects. It has no effect on the exudative effects of corticosteroids.
1.2. Inhibitory Effects on Arachidonic Acid Metabolizing Enzymes: Glycyrrhizic acid glycoside directly binds to phospholipase A2, the initiating enzyme in the arachidonic acid metabolic pathway, and to lipoxygenase, which reacts to arachidonic acid to produce inflammatory mediators. It selectively inhibits the phosphorylation and activation of these enzymes. 2. Immunomodulatory Effects: Glycyrrhizin has been shown to have the following immunomodulatory effects in vitro: 2.1. Regulation of T cell activation; 2.2. Induction of interferon-γ; 2.3. Activation of NK cells; 2.4. Promotion of extrathymic T lymphocyte differentiation. 3. Inhibition of experimental hepatocyte injury: In vitro, glycyrrhizin inhibited carbon tetrachloride-induced hepatocyte injury in primary cultured rat hepatocytes. 4. Hepatocyte Proliferation Promotion: Glycyrrhizin and glycyrrhetinic acid promoted hepatocyte proliferation in vitro in primary cultured Wistar rat hepatocytes. 5. Inhibition of viral proliferation and inactivation: In experiments with MHV (murine hepatitis virus) infection in dd-line mice, administration of glycyrrhizin prolonged their survival. In a rabbit vaccinia virus pox prevention experiment, it demonstrated an anti-pox effect. In vitro studies have also demonstrated anti-herpes virus proliferation and viral inactivation. Glycine and methionine have been reported to inhibit the decrease in urine volume and sodium excretion induced by oral administration of glycyrrhizin to Wistar/KY rats.
[Storage]
Store at room temperature.
[Specifications]
Each tablet contains 25 mg of glycyrrhizin, 25 mg of glycine, and 25 mg of methionine.
[Packaging]
Packaging in PTP aluminum foil, pharmaceutical-grade PVC rigid blister pack, 30 tablets/box.
[Expiration Date]
24 months.
[Approval Number]
National Medicine Standard H20073723
[Manufacturer]
Company Name: Lepu Pharmaceutical Co., Ltd.
