Product Overview
[Drug Name]
Generic Name: Felodipine Tablets
Trade Name: Lianhuanerding
English Name: Felodipine Tablets
Chinese Pinyin: Feiluodiping Pian
[Ingredients]
The main ingredient of this product is felodipine. Its chemical name is 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3-pyridinedicarboxylic acid ethyl ester methyl ester. Molecular Formula: C₁₈H₁₉Cl₂NO₄ Molecular Weight: 384.25
[Appearance]
White or off-white tablets.
[Indications]
For the treatment of mild to moderate essential hypertension.
[Dosage and Administration]
Oral: Starting dose: 2.5 mg twice daily, or as directed by a physician. The usual maintenance dose is 5 mg or 10 mg daily. The dose can be increased if necessary, or other antihypertensive medications can be added.
[Adverse Reactions]
1. This drug, like other calcium channel blockers, can cause flushing, headache, dizziness, palpitations, and fatigue in some patients. Most of these reactions are dose-dependent, begin within a short period of time after the dose is increased, are transient, and disappear with prolonged use.
2. This drug, like other dihydropyridines, can cause dose-related ankle swelling and mild gingival swelling in patients with gum or periodontitis.
3. Rash and itching may also occur.
4. In rare cases, significant hypotension with tachycardia may occur, which may cause myocardial hypoxia in susceptible individuals.
[Contraindications]
This drug should not be used in patients with hypersensitivity.
[Precautions]
This drug can rarely cause significant hypotension with tachycardia, which may cause myocardial hypoxia in susceptible individuals. Overdose can cause excessive peripheral vasodilation, accompanied by significant hypotension and sometimes bradycardia. Symptomatic treatment should be given if severe hypotension occurs, such as placing the patient supine with the legs elevated. If bradycardia is present, atropine 0.5-1.0 mg should be administered intravenously. If this effect is inadequate, glucose should be infused. Saline and dextran should be used to expand blood volume. If the above measures are ineffective, sympathomimetic amines that primarily act at alpha-adrenergic receptors can be administered.
[Use in Special Populations]
Precautions for Children: This study has not been conducted and no reliable references are available.
Precautions for Pregnancy and Lactation: This product is contraindicated in pregnant women and those allergic to it.
Precautions for the Elderly: This study has not been conducted and no reliable references are available.
[Drug Interactions]
1. Concomitant use of drugs that affect cytochrome P450 enzymes while taking this product may affect felodipine blood levels. 2. Enzyme-inducing drugs (such as phenytoin, carbamazepine, and barbiturates) can decrease felodipine blood levels. 3. Enzyme inhibitors (such as cimetidine) can increase felodipine blood levels. Although felodipine has a high degree of plasma protein binding, it does not affect the binding of other plasma protein-bound drugs (such as warfarin).
[Pharmacological Action]
This drug is a selective calcium antagonist that primarily inhibits extracellular calcium influx into arteriolar smooth muscle cells, selectively dilating arterioles without affecting veins. It does not cause postural hypotension and has no significant inhibitory effect on the myocardium. While reducing renal vascular resistance, it does not affect glomerular filtration rate and creatinine clearance, and renal blood flow remains unchanged or may even slightly increase. It has natriuretic and diuretic effects. It increases cardiac output and cardiac index, significantly reduces afterload, and has no significant effect on cardiac systolic function, preload, or heart rate.
[Storage] Store in a dark, sealed container.
[Strength] 2.5 mg
[Packaging Size] 2.5 mg x 24 tablets
[Expiry Date] 36 months
[Approval Number] National Medicine Standard H10970111
[Manufacturer] Company Name: Jiangsu Lianhuan Pharmaceutical Co., Ltd.
