Product Overview
[Drug Name]
Generic Name: Urapidil Sustained-Release Tablets
Trade Name: Lixiding
English Name: Urapidil Sustained-Release Tablets
Chinese Pinyin: Wuladi'er Huanshi Pian
[Ingredients]
The main ingredient of this product is urapidil, chemically known as 6-[[3-[4-(0-methoxyphenyl)-1-piperazinyl]-propyl]-1,3-dimethyluracil
[Properties]
This product is a white tablet.
[Indications]
An α-receptor blocker, indicated for the treatment of essential hypertension, renal hypertension, and hypertension caused by pheochromocytoma.
[Dosage and Administration]
For adults, the usual dosage of urapidil is 30 mg/day. If the effect is not significant, the dose can be gradually increased to 60 mg or 120 mg per day over 1 to 2 weeks, taken orally in two divided doses. The dosage can be increased or decreased based on age and symptoms.
[Adverse Reactions]
Headache, dizziness, nausea, vomiting, fatigue, palpitations, arrhythmias, itching, and insomnia may occur. Overdose or rapid increases in initial dosage may cause dizziness, orthostatic hypotension, collapse, and fatigue. Symptomatic treatment should be administered if necessary. Occasionally, loss of appetite, stomach discomfort, diarrhea, edema, and elevated GOT, GPT, and CPK may occur.
[Contraindications]
1. Allergic reactions to this product. 2. Pregnant and lactating women.
[Precautions]
1. Use with caution if driving or operating machinery. 2. Avoid use with alcoholic beverages. 3. Use with caution in the elderly and in patients with liver dysfunction. 4. This product may enhance its antihypertensive effect when used in combination with other antihypertensive drugs. Concomitant use with cimetidine may increase the blood concentration of this product. 5. Because this product is a sustained-release formulation, it should not be chewed or crushed to prevent a transient increase in blood concentrations.
[Use in Special Populations]
Precautions for Children: Not yet available.
Precautions for Pregnancy and Lactation: This product is contraindicated in pregnant and lactating women.
Precautions for Elderly: Antihypertensive drugs should be used with caution in elderly patients, and initial doses should be low, as their sensitivity to drugs can be difficult to assess.
[Drug Interactions]
Not yet available.
[Pharmacological Actions]
Urapidil is a highly selective α-receptor blocker with both peripheral and central effects. Its peripheral vasodilatory effect is primarily due to blockade of postsynaptic α-receptors, significantly reducing peripheral resistance. It also moderately blocks the vasoconstrictive effects of catecholamines. Its central effect is to lower blood pressure by activating serotonin-1A receptors, reducing sympathetic feedback regulation in the medullary cardiovascular center. This action is without the side effect of reflex heart rate tachycardia and may improve hemodynamic parameters.
[Storage]
Store tightly closed in a cool, dry place.
[Specifications]
30mg x 20 tablets
[Expiration Period]
24 months
[Approval Number]
National Medicine Standard H20000463
[Manufacturer]
Company Name: Xi'an Lijun Pharmaceutical Co., Ltd.
