Product Overview
[Drug name]
Generic name: Compound Metronidazole Vaginal Suppository
Trade name: Subixin Compound Metronidazole Vaginal Suppository 3g*7 pieces
Pinyin full code: DingZhouPai FuFangJiaXiaoZuoYinDaoShuan 3g*7Mei
[Main ingredients]
This product is a compound preparation, and its components are: metronidazole, nystatin, tetracycline.
[Properties]
This product is a brown or brownish yellow torpedo-shaped suppository. This product is a white or slightly yellow suppository.
[Indications/Main functions]
Anti-trichomoniasis and antibiotic drugs, used to treat trichomonas vaginitis, candidal vaginitis, bacterial vaginitis and senile vaginitis, nonspecific vaginitis and mycoplasma infection, gonorrhea diplococcus infection and other diseases.
[Precautions]
If this product becomes soft in hot weather, it can be used after refrigeration for 5-10 minutes without affecting the efficacy.
【Drug Interactions】
Patients who are allergic to this product or azole drugs and patients with active central nervous system diseases and blood diseases are prohibited from using this product.
【Children's Use】
Children should use it with caution.
【Elderly Patients' Use】
Due to decreased liver function, the pharmacokinetics of this product are changed when the elderly use it, so it should be used with caution.
【Pregnant and Lactating Women's Use】
Animal experiments have found that metronidazole is toxic to the fetus after intraperitoneal administration. However, there is currently a lack of sufficient and rigorous controlled studies on pregnant and lactating women. Therefore, pregnant and lactating women are prohibited from using this product.
【Specifications】
3g*7 tablets
【Usage and Dosage】
Vaginal administration. For general symptoms, take one tablet a day, every night, and a course of treatment of 6 days. It should be used for two courses of treatment. Severe patients can take two tablets a day, one tablet each in the morning and evening, and a course of treatment of 6 days, and at least two courses of treatment.
【Adverse Reactions】
This product is non-toxic and has no effect. Local adverse reactions are rare. Because this product can be absorbed from the mucosa, long-term and large-scale use can also produce the same adverse reactions as systemic medication: 1. It can cause epileptic seizures and peripheral neuropathy, the latter of which is mainly manifested by numbness and paresthesia of the extremities. In some cases, long-term use of the drug can cause persistent peripheral neuropathy. 2. Other common adverse reactions include: (1) Gastrointestinal reactions, such as nausea, loss of appetite, vomiting, diarrhea, abdominal discomfort, taste changes, dry mouth, metallic taste in the mouth, etc. (2) Reversible neutropenia. (3) Allergic reactions, rashes, urticaria, itching, etc. (4) Central nervous system symptoms, such as headache, dizziness, syncope, paresthesia, limb numbness, ataxia and mental confusion. (5) Other symptoms include elevated serum aminotransferase, fever, cystitis, dysuria, dark urine color, etc., which are all reversible and will recover on their own after stopping the drug.
[Contraindications]
This product is contraindicated for patients who are allergic to this product or azole drugs and patients with active central nervous system diseases and blood diseases.
【Overdose】
Not clear yet.
【Pharmacology and Toxicology】
Metronidazole: Metronidazole has a strong antibacterial effect on most anaerobic bacteria, but has no effect on aerobic bacteria and facultative anaerobes. The antibacterial spectrum includes Bacteroides fragilis and other Bacteroides, Fusobacterium, Clostridium perfringens, Eubacterium, Veillonella, Peptococcus and Peptostreptococcus. Its bactericidal concentration is slightly higher than the inhibitory concentration. In addition, it also has a strong killing effect on amoeba and Trichomonas. The bactericidal mechanism of metronidazole has not been fully elucidated. The nitroreductase of anaerobic bacteria plays an important role in the energy metabolism of sensitive strains. The nitro reduction of this product is a cytotoxin, which acts on the DNA metabolism process of bacteria and promotes cell death. The mechanism of anti-amoeba is to inhibit its redox reaction and break the nitrogen chain of the protozoa. Ginseng stem and leaf saponins and vitamin E have the effect of promoting the healing of mucosal and skin wounds.
[Pharmacokinetics] This product is a topical drug, part of which can be absorbed through the mucous membrane, of which metronidazole accounts for about 20% to 25% of the administered dose. After absorption, metronidazole is widely distributed in various tissues and body fluids, and can pass the blood-cerebrospinal fluid barrier. 60% to 80% is excreted through the kidneys, of which 20% is the original form and the rest is metabolites. A small part is excreted with feces or from the skin.
