Product Overview
[Drug Name]
Generic Name: Isosorbide Mononitrate Sustained-Release Tablets
Trade Name: Xinkang
English Name: Isosorbide Mononitrate Sustained-Release Tablets
Chinese Pinyin: Danxiaosuan Yishanlizhi Huanshi Pian
[Ingredients]
Main ingredient: Isosorbide mononitrate. Chemical name: 1,4;3,6-dianhydro-D-sorbitol-5-nitrate.
[Properties]
This product is a film-coated tablet. After removing the film coating, it is a white or off-white double-layer tablet.
[Indications]
For the long-term treatment of coronary heart disease; prevention of angina pectoris; treatment of persistent angina pectoris after myocardial infarction; combined with digitalis and/or diuretics for the treatment of chronic congestive heart failure.
[Dosage and Administration]
Oral: Take one tablet daily in the morning. For severe cases, take two tablets daily in the morning. If headache occurs, the initial dose can be reduced to half a tablet daily. Keep the whole or half tablet intact before use and swallow with half a glass of water. Do not chew or crush.
[Adverse Reactions]
Nitrates may cause vasodilatory headaches at the beginning of treatment, which usually disappear after a few days of continuous use. Facial flushing, dizziness, orthostatic hypotension, and reflex tachycardia may also occur. Rarely, a significant decrease in blood pressure, bradycardia, exacerbated angina, and syncope may occur.
[Contraindications]
This medication is contraindicated in patients with glaucoma, shock, significant hypotension, hypertrophic obstructive heart disease, acute myocardial infarction, or severe cerebral arteriosclerosis.
[Precautions]
1. Use with caution in patients with acute myocardial infarction and low ventricular filling pressure. 2. Use with caution in patients with postural circulatory disorders. 3. Not for use in acute attacks of angina.
[Use in Special Populations]
Precautions for use in children:
This study has not been conducted and no reliable references are available.
Precautions for pregnancy and lactation:
Use with caution in pregnant and lactating women.
Precautions for Elderly Patients:
This study has not been conducted and no reliable references are available.
[Drug Interactions]
Not yet known.
[Pharmacological Actions]
Isosorbide mononitrate is the primary active metabolite of isosorbide dinitrate. It can reduce myocardial oxygen consumption by dilating peripheral blood vessels, particularly increasing venous blood volume, reducing reflux, and lowering cardiac preload and postload. It can also improve blood flow to the ischemic area by promoting myocardial blood flow redistribution, potentially exerting its anti-ischemic effects through these two mechanisms.
[Storage]
Store in a dark, airtight container.
[Strength]
40 mg
[Packaging]
Aluminum-plastic packaging, 36 tablets/box.
[Expiry Period]
36 months
[Approval Number]
National Medicine Standard H19991039
[Manufacturer]
Company Name: Lunan Beite Pharmaceutical Co., Ltd.
