Product Overview
【Drug name】
Generic name: Bromocriptine mesylate tablets
Trade name: Novartis Bromocriptine mesylate tablets 2.5mg*30 tablets
Pinyin full code: NuoHua JiaHuangSuanZuoYinTingPian 30Pian
【Main ingredients】
The active ingredient of this product is bromocriptine mesylate.
【Properties】
This product is a white tablet.
【Indications/Main functions】
1. Postpartum, spontaneous, tumor-induced, and drug-induced amenorrhea. 2. Menstrual disorders, infertility, and secondary amenorrhea caused by prolactin, and decreased ovulation. 3. Inhibit lactation and prevent lactation after delivery and premature birth. 4. Postpartum breast congestion, special breast tenderness, breast pain, and irritability caused by prolactin. 5. Prolactin-induced hypoandrogenism, such as impotence and infertility caused by reduced sperm. 6. Auxiliary treatment of acromegaly. 7. Anti-Parkinson-Dole: This product has a rapid onset of effect and a long duration.
【Precautions】
1. If used in combination with levodopa, the efficacy can be improved, but the use of 10 mg of this product requires a 12.5% reduction in the dose of levodopa. 2. The main adverse reactions include nausea, headache, dizziness, fatigue, abdominal pain, vomiting, etc., and hypotension, hyperactivity, movement disorders and mental symptoms may also occur. The incidence of adverse reactions is about 68%. It can be alleviated after continuous use of the drug, and it can also be alleviated when taken with food. About 3% need to stop taking the drug. 3. It is used to treat amenorrhea or galactorrhea, which can produce short-term effects and should not be used for a long time. Pregnancy is allowed during treatment. If family planning is required, contraceptives without estrogen or other measures should be used. 4. It is contraindicated for people who are allergic to ergot alkaloids, heart disease, peripheral vascular disease, and women during pregnancy. 5. Avoid using it in combination with antihypertensive drugs, phenothiazines or H2 receptor blockers.
【Drug Interactions】
Bromocriptine mesylate tablets are contraindicated if you are allergic to any of the ingredients. In psychiatry, spontaneous and familial tremors, severe cardiovascular diseases, various types of endogenous mental illnesses, untreated hypertension, pregnancy toxemia, and allergies to other ergot alkaloids are contraindicated.
【Pregnant and lactating women】
Bromocriptine mesylate tablets should not be taken by lactating women. After pregnancy, this product should usually be discontinued after the first menopause. Pituitary tumors sometimes grow rapidly during pregnancy, which can also occur in women who are able to become pregnant after treatment with bromocriptine mesylate tablets. For the sake of caution, patients should be closely monitored to detect signs of pituitary enlargement, so that bromocriptine mesylate tablets can be used again when necessary. In special circumstances such as after miscarriage, stillbirth, and neonatal death, it is used to suppress puerperal lactation under the guidance of a doctor. It is not recommended as a routine medication to suppress natural lactation.
【Specification】
2.5mg*30 tablets (Novartis)
【Usage and Dosage】
Bromocriptine should be taken during meals. A. Endocrinology indications Menstrual disorders and female infertility: 1.25mg (half tablet)/time, 2-3 times a day. If the effect is not significant, it can be gradually increased to 2.5mg (1 tablet)/time, 2-3 times a day. Continue treatment until the menstrual cycle returns to normal and/or ovulation resumes. If necessary, continuous treatment can be continued for more than several menstrual cycles to prevent recurrence. Male hyperprolactinemia: 1.25mg (half tablet)/time, 2-3 times a day. Gradually increase to 5-10mg (2-4 tablets)/day. Prolactinoma: 1.25mg (half tablet)/time, 2-3 times a day. Gradually increase to several tablets or several pills a day to ensure that the prolactin level in plasma is controlled. Acromegaly: Start with 1.25 mg (half a tablet)/time, 2-3 times a day, monitor clinical response and adverse reactions, and gradually increase to 10-20 mg/day. Early postpartum mastitis: Same as the dose for inhibiting lactation (see below). Use with antibiotics if necessary. Inhibiting lactation: Take 1.25 mg (half a tablet) each at breakfast and dinner on the first day of treatment, followed by 2.5 mg (1 tablet)/time, twice a day, for 14 days. To prevent lactation, treatment should be started within a few hours after delivery or abortion, but not before vital signs are stable. Occasionally, a small amount of milk secretion will occur 2-3 days after the termination of treatment. At this time, treatment can be continued for another week at the same dose. Or follow the doctor's advice. Pediatric (11-17 years old) medication: Prolactinoma: Based on the limited data available for children aged 11-17 years, the initial dose is half to one 2.5 mg tablet per day. It can be gradually increased to several tablets per day based on tolerance. In order to fully suppress plasma prolactin levels, the maximum daily dose recommended for prolactinoma patients in this age group (11-17 years old) is 10 mg. B. Neurological indications In order to obtain the best tolerance, treatment should be started with a low dose of 1.2 mg (half a tablet) per day. It is recommended to take the medicine at night in the first week. The daily dose can be increased by 1.25 mg per week. Until the minimum effective dose is reached: the daily dose is usually taken in 2-3 times. If satisfactory efficacy is not achieved within 6-8 weeks. You can try to increase the dose by 2.5 mg/day per week. During the dose adjustment phase, if adverse reactions occur, the daily dose should be reduced for at least one week. Once the adverse reactions disappear, the dose should be increased again as soon as possible. For patients who develop dyskinesias while using levodopa, the dose of levodopa should be reduced before using bromocriptine. When satisfactory efficacy is achieved, the dose of levodopa should be gradually reduced. In some patients, levodopa can even be completely discontinued. Bromocriptine is usually dosed at 10-40 mg per day when used alone or in combination with other drugs. Some patients may require higher doses.
【Adverse Reactions】
Nausea, vomiting, constipation in rare cases, drowsiness, and occasional psychiatric symptoms.
【Contraindications】
Allergy to any of the ingredients in bromocriptine mesylate tablets is contraindicated. In psychiatry, spontaneous and familial tremor, severe cardiovascular disease, various types of endogenous psychosis, untreated hypertension, pregnancy toxemia, and allergies to other ergot alkaloids are contraindicated.
【Overdose】
Acute overdose can be given with metoclopramide (Metoclopramide), preferably parenterally. Overdose of bromocriptine mesylate tablets may cause vomiting and other symptoms due to overstimulation of dopamine receptors, and may also cause mental confusion, hallucinations, and hypotension. The general treatment method is to remove all unabsorbed drugs and maintain normal blood pressure if necessary.
