Product Overview
[Drug Name]
Generic Name: Domperidone Tablets
Trade Name: NuoJieKang Domperidone Tablets 10mg*24 Tablets
Pinyin Code: NuoJieKang DuoPanLiTongPian 10mg*24 Tablets
[Main Ingredients]
The main ingredient of this product is domperidone.
[Properties]
This product is white tablets.
[Indications/Main Functions]
Used for indigestion, abdominal distension, belching, nausea, vomiting, and abdominal pain.
[Specifications]
10mg*24 tablets
[Dosage and Administration]
Oral. Adults: 1 tablet three times daily, 15-30 minutes before meals.
[Adverse Reactions]
1. Occasionally, mild abdominal cramps, dry mouth, rash, headache, diarrhea, nervousness, fatigue, drowsiness, and dizziness may occur.
2. Occasionally, serum prolactin levels may be elevated, leading to galactorrhea and gynecomastia in men, but these symptoms return to normal after discontinuation of the drug.
3. Amenorrhea may occur in rare cases.
4. Extrapyramidal side effects (such as drooling and hand tremors) may occur in extremely rare cases, but these symptoms resolve completely on their own after discontinuation of the drug.
5. Occasionally, transient, mild abdominal cramping may occur.
6. Serum prolactin levels may be elevated, but these symptoms return to normal after discontinuation of the drug. This effect is similar to that seen with many other medications.
[Contraindications]
1. This product is contraindicated in patients with allergies.
2. This product is contraindicated in patients with pheochromocytoma, breast cancer, mechanical intestinal obstruction, or gastrointestinal bleeding.
[Precautions]
1. This product is contraindicated in patients with allergies.
2. This product is contraindicated in patients with pheochromocytoma, breast cancer, mechanical intestinal obstruction, or gastrointestinal bleeding.
3. Domperidone suspension is recommended for children.
4. Use with caution in pregnant women.
5. Caution is advised when using this product in patients with heart disease (arrhythmias) or cancer patients undergoing chemotherapy, as it may worsen heart rhythm disorders.
6. In case of overdose or serious adverse reactions, seek medical attention immediately.
7. Do not use if the product's properties change.
8. Keep this product out of reach of children.
[Drug Interactions]
1. Do not use this product with azole antifungals such as ketoconazole and itraconazole, macrolide antibiotics such as erythromycin, HIV protease inhibitors, and nefazodone.
2. Anticholinergic drugs such as tadalafil, propantheline bromide, anisodamine, and belladonna tablets can weaken the effects of this product and should not be taken with this product.
3. Antacids and drugs that inhibit gastric acid secretion can reduce the bioavailability of this product and should not be taken with this product.
4. Concomitant use with other medications may cause drug interactions. Please consult your physician or pharmacist for details.
[Pediatric Use]
Due to the immature development of the blood-cerebrospinal fluid (CSF) barrier in children under one year of age, the possibility of central nervous system side effects cannot be ruled out.
[Elderly Use]
Follow medical advice.
[Pregnant and Breastfeeding Use]
Use with caution during pregnancy.
[Overdose]
The potential for overdose is unknown.
[Pharmacology and Toxicology]
This drug is a peripheral dopamine receptor blocker that acts directly on the gastrointestinal wall. It increases the tone of the lower esophageal sphincter, prevents gastroesophageal reflux, enhances gastric motility, promotes gastric emptying, coordinates gastric and duodenal motility, inhibits nausea and vomiting, and effectively prevents bile reflux without affecting gastric secretion. This drug does not readily cross the blood-cerebrospinal fluid (CSF) barrier and has no inhibitory effect on brain dopamine receptors. Therefore, it is not expected to cause extrapyramidal or other neurological or psychiatric adverse reactions.
[Pharmacokinetics]
After oral administration, it is rapidly absorbed, reaching peak plasma concentrations within 15-30 minutes. The highest concentration is in the gastrointestinal tract, followed by plasma, with virtually no drug present in the brain. This drug is almost entirely metabolized in the liver, with a half-life (t½) of 7 hours. Urinary excretion accounts for 31.23%, with unchanged drug accounting for 0.4%. Fecal excretion accounts for 65.7%, with unchanged drug accounting for 10%.
[Storage]
Sealed
[Expiry Period]
36 months
[Approval Number]
National Drug Approval No. H20084577
[Manufacturer]
Heilongjiang Nuojie Pharmaceutical Co., Ltd.
