Product Overview
【Drug name】
Generic name: Shuangzuotai suppository
Trade name: Kuihua Shuangzuotai suppository 8 tablets
Pinyin full code: KuiHua ShuangZuoTaiShuan 8Li
【Main ingredients】
This product is a compound preparation, each tablet contains the main ingredients of metronidazole, clotrimazole, and chlorhexidine acetate.
【Properties】
This product is a milky yellow duckbill or bullet-shaped suppository.
【Indications/Main functions】
It is used for bacterial vaginitis, candidal vaginitis, trichomonas vaginitis, and mixed infectious vaginitis.
【Precautions】
1. Shuangzuotai suppository is only for vaginal administration, and oral administration is strictly prohibited. 2. Avoid menstruation when using Shuangzuotai suppository. 3. Women with no sexual history should use it under the guidance of a physician. 4. If there is a burning sensation, redness, swelling, etc. at the medication site, stop taking the medication, wash the local medication, and consult a physician if necessary. 5. Wash your hands or wear cots or gloves when administering. 6. Pay attention to personal hygiene during medication, prevent repeated infection, use condoms or avoid sexual intercourse. 7. Breastfeeding women should stop breastfeeding when using bisoprolol suppositories. 8. Elderly people should use with caution. 9. If allergic symptoms or adverse reactions of the central nervous system occur during use, the drug should be discontinued immediately. 10. Use with caution in patients with liver and kidney dysfunction. 11. When treating vaginal trichomoniasis, their sexual partners must be treated at the same time. 12. Do not drink alcohol or beverages containing alcohol during the use of bisoprolol suppositories. 13. Patients who are allergic to bisoprolol suppositories are prohibited from use, and those with allergic constitutions should use with caution. 14. Bisoprolol suppositories are prohibited from use when their properties change. 15. Please keep bisoprolol suppositories out of reach of children. 16. If you are using other drugs, please consult a doctor or pharmacist before using bisoprolol suppositories.
【Drug Interactions]
1. Patients who are allergic to this product or pyrrole (imidazole) drugs and patients with active central nervous system diseases and blood diseases are prohibited from use. 2. Pregnant women are prohibited from using this product.
【Drug use in children】
Children should use this product with caution.
【Drug use in elderly patients】
Due to decreased liver function, the pharmacokinetics of this product are changed when used in the elderly, so it should be used with caution.
【Drug use in pregnant women and lactating women】
Animal experiments have found that metronidazole and clotrimazole are toxic to the fetus after intraperitoneal or oral administration. However, there is currently a lack of sufficient and rigorous controlled studies on pregnant and lactating women. Therefore, pregnant women are prohibited from using this product, and lactating women should stop breastfeeding when using this product.
【Specification model】
8 tablets
【Usage and dosage】
For vaginal administration, wash your hands before going to bed, take the suppository, remove the outer packaging, put on a finger cot, and send this product deep into the vagina (posterior fornix), 1 tablet each time, and use it for 7 consecutive days as a course of treatment. Repeat one course of treatment after the first menstruation after stopping the drug.
【Adverse reactions】
Occasionally, rash, vaginal burning sensation, itching or other mucosal irritation symptoms may occur. Because this product can be absorbed from the mucosa, long-term and large-scale use can also produce the same adverse reactions as systemic medication: 1. It can cause epileptic seizures and peripheral neuropathy, the latter of which is mainly manifested as numbness and paresthesia of the extremities. In some cases, long-term use of the drug can cause persistent peripheral neuropathy. 2. Other common adverse reactions include: (1) Gastrointestinal reactions, such as nausea, loss of appetite, vomiting, diarrhea, abdominal discomfort, taste changes, dry mouth, metallic taste in the mouth, etc. (2) Reversible granulocytopenia. (3) Allergic reactions, such as rash, urticaria, itching, etc. (4) Central nervous system symptoms, such as headache, dizziness, syncope, paresthesia, limb numbness, ataxia and mental confusion. (5) Other symptoms include elevated serum aminotransferase, fever, cystitis, dysuria, dark urine color, etc., which are all reversible and will recover on their own after stopping the drug.
【Contraindications】
1. Patients who are allergic to this product or pyrrole (imidazole) drugs and patients with active central nervous system diseases and blood diseases are prohibited from using it. 2. Pregnant women are prohibited from using it.
【Overdose】
It is not clear yet.
【Pharmacology and Toxicology】
1. Metronidazole: Metronidazole has a strong antibacterial effect on most anaerobic bacteria, but has no effect on aerobic bacteria and facultative anaerobes. The antibacterial spectrum includes Bacteroides fragilis and other Bacteroides, Fusobacterium, Clostridium perfringens, Eubacterium, Veillonella, Peptococcus and Peptostreptococcus, etc. Its bactericidal concentration is slightly higher than the inhibitory concentration. In addition, it also has a strong killing effect on amoeba and Trichomonas. The bactericidal mechanism of metronidazole has not been fully elucidated. The nitroreductase of anaerobic bacteria plays an important role in the energy metabolism of sensitive strains. The nitro group of this product is reduced to a cytotoxin, which acts on the DNA metabolism process of bacteria and promotes cell death. The mechanism of anti-amoeba is to inhibit its redox reaction and break the nitrogen chain of the protozoa. 2. Clotrimazole: It has antibacterial effect and can also have bactericidal effect at high concentration. It can inhibit the biosynthesis of fungal ergosterol and other sterols; damage the fungal cell membrane nucleus to change its permeability, causing the leakage of important substances in the cell; it can also inhibit the biosynthesis of triglycerides and phospholipids in fungi; it can also inhibit the activity of oxidation and peroxidase, causing excessive accumulation of peroxides in the cell, leading to degeneration and necrosis of fungal subcellular structures. 3. Chlorhexidine acetate: This product is an antibacterial and anti-inflammatory drug. Some Staphylococci, Streptococcus mutans, Streptococcus salivarius, Candida albicans, Escherichia coli and anaerobic propionibacterium are highly sensitive to this product; Haemophilus Streptococcus is moderately sensitive, and Proteus, Pseudomonas, Klebsiella and Gram-negative cocci are lowly sensitive. Chlorhexidine can be adsorbed on the mucosal surface due to its positive charge, and gradually diffuse and release from the adsorption site, producing a sustained antibacterial effect. It can be adsorbed on the permeability barrier of the bacterial cytoplasmic membrane, causing the cell contents to leak out, inhibiting bacteria at low concentrations and killing bacteria at high concentrations.
【Pharmacokinetics】
This product is a topical medication, partially absorbed through the mucosa. The absorption of metronidazole and clotrimazole is approximately 20% to 25% and 3% to 10% of the dose, respectively, and the absorption of chlorhexidine acetate is very small. After absorption, metronidazole is widely distributed in various tissues and body fluids, and can pass through the blood-cerebrospinal fluid barrier. 60% to 80% is excreted through the kidneys, of which 20% is the original form and the rest is metabolites. A small part is excreted with feces or from the skin. After absorption, clotrimazole is metabolized into inactive metabolites in the liver and excreted with feces and urine.
