Product Overview
[Drug Name]
Generic Name: Metoclopramide Tablets
Brand Name: Pengyao Metoclopramide Tablets 5mg*100 tablets/bottle
Pinyin Code: PengYao JiaYangLvPuAnPian
[Main Ingredients]
Metoclopramide
[Appearance]
This product is a white tablet.
[Indications/Main Functions]
Antiemetic. Mainly used for:
1. Symptomatic treatment of nausea, vomiting, belching, indigestion, abdominal distension, and hyperacidity caused by various etiologies;
2. Reflux esophagitis, bile reflux gastritis, functional gastric retention, gastroptosis, etc.;
3. Delayed gastric emptying after vagotomy;
4. Gastric emptying disorders caused by collagen diseases such as diabetic gastroparesis, uremia, and scleroderma.
[Specifications】
5mg*100 tablets/bottle
[Dosage and Administration】
Oral administration: Usual adult dose. (1) 5-10 mg each time, 3 times a day. For patients with diabetic gastric emptying dysfunction, take 10 mg orally 30 minutes before the onset of symptoms; or take 5-10 mg before meals and bedtime, 4 times a day. (2) The total daily dose for adults should not exceed 0.5 mg/kg. Commonly used dose for children. (1) For children aged 5-14 years, take 2.5-5 mg each time, 3 times a day, 30 minutes before meals. Short-term use is recommended. (2) The total daily dose for children should not exceed 0.1 mg/kg.
[Adverse Reactions]
1. Common adverse reactions include: drowsiness, restlessness, fatigue;
2. Less common reactions include: breast swelling and pain, nausea, constipation, rash, diarrhea, sleep disturbances, dizziness, severe thirst, headache, and irritability;
3. Increased milk production may occur during medication due to the stimulation of prolactin;
4. Long-term use of high doses may lead to extrapyramidal reactions (especially in young people) due to the blockade of dopamine receptors, resulting in relative hyperactivity of cholinergic receptors. Symptoms may include muscle tremors, difficulty speaking, and ataxia.
[Contraindications】
1. The following conditions are contraindicated: (1) Hypersensitivity to procaine or procainamide; (2) Increased frequency and severity of epileptic seizures due to medication; (3) Gastrointestinal bleeding, mechanical intestinal obstruction, or perforation may worsen due to increased gastrointestinal motility; (4) Hypertensive crisis may occur in pheochromocytoma patients due to medication; (5) Not for use in breast cancer patients experiencing vomiting due to chemotherapy or radiotherapy.
2. Use with caution in the following conditions: (1) Liver failure, resulting in loss of protein binding capacity; (2) Renal failure, i.e., severe chronic renal failure, increases the risk of extrapyramidal reactions, and the dosage should be reduced.
[Drug Interactions】
1. When used concurrently with acetaminophen, levodopa, lithium compounds, tetracycline, ampicillin, ethanol, and diazepam, gastric emptying is accelerated, leading to increased absorption of the latter in the small intestine.
2. Concurrent use with ethanol or central nervous system depressants enhances the sedative effect.
3. It has antagonistic effects when used with anticholinergic drugs and anesthetic analgesics.
4. When used with antimuscarinic narcotic sedatives, the motility of metoclopramide in the gastrointestinal tract can be neutralized.
5. Due to its catecholamine release, it should be monitored in hypertensive patients using monoamine oxidase inhibitors.
6. Concurrent use with acetaminophen, tetracycline, levodopa, ethanol, and cyclosporine can increase its absorption in the small intestine.
7. Concurrent use with apomorphine inhibits both the central and peripheral effects of the latter.
8. Concomitant use with cimetidine and slow-dissolving digoxin reduces gastrointestinal absorption of the latter. Dosing the doses two hours apart can reduce this effect. This drug may also increase digoxin excretion in the bile, thereby altering its blood concentration.
9. Concomitant use with drugs that can cause extrapyramidal reactions, such as phenothiazines, may increase the incidence and severity of extrapyramidal reactions.
[Precautions]
1. Aldosterone and serum prolactin levels may be elevated with metoclopramide.
2. The dose should be reduced by at least 60% in patients with severe renal impairment, as these patients are prone to extrapyramidal symptoms.
3. Because this drug can reduce the oral bioavailability of cimetidine, if the two drugs must be used together, an interval of at least one hour should be maintained.
4. This drug becomes toxic after turning yellow or yellow-brown in light.
[Pediatric Use]
Children should not use this drug for long periods of time.
[Elderly Use]
Elderly patients should avoid long-term, high-dose use, as this can easily lead to extrapyramidal symptoms.
