Product Overview
[Drug Name]
Generic Name: Ursodeoxycholic Acid Tablets
Trade Name: Pyrilofursodeoxycholic Acid Tablets 0.25g*24 Tablets
Pinyin Code: ZuoFu XiongQuYangDanSuanPian 0.25g*24 Tablets
[Main Ingredients]
Ingredient: Ursodeoxycholic acid. Chemical Name: 3α,7β-dihydroxy-5β-cholestane-24-oic acid. Molecular Formula: C24H40O4. Molecular Weight: 392.58
[Properties]
This product is a white tablet.
[Indications/Main Functions]
1. Cholesterol gallstones - must be X-ray-translucent and have normal gallbladder contraction function; 2. Cholestatic liver disease (e.g., primary biliary cirrhosis); 3. Bile reflux gastritis
[Specifications]
0.25g*24 tablets
[Dosage and Administration]
1. Cholesterol gallstones and cholestatic liver disease: Take regularly with a small amount of water. The daily dose is 10 mg/kg based on body weight. Litholytic treatment: Generally requires 6-24 months. If the stone does not decrease after 12 months, discontinue use. Treatment results are assessed by ultrasound or X-ray examination every 6 months. 2. Bile reflux gastritis: Take with water at night before bed. Take regularly, one tablet (0.25g) once daily for 10-14 days. Continuation is determined based on the patient's discretion.
[Adverse Reactions]
This product has less toxicity and side effects than chenodeoxycholic acid and generally does not cause diarrhea. Other occasional adverse reactions include constipation, allergies, headache, dizziness, pancreatitis, and tachycardia.
[Contraindications]
This product is contraindicated in patients with complete biliary obstruction and severe liver dysfunction.
[Drug Interactions]
(1) Contraceptives can increase bile saturation. When using this product for treatment, other birth control measures should be taken as much as possible to avoid affecting the efficacy. (2) Cholestyramine (cholestyramine), colestipol (colestipol) and aluminum-containing antacids can bind to CDCA and reduce its absorption. They should not be used together.
[Precautions]
1. Long-term use of this product can increase the number of peripheral platelets. 2. If repeated biliary colic attacks occur during the treatment of cholesterol stones, the symptoms do not improve or even worsen, or obvious stone calcification occurs, treatment should be discontinued and surgical operation should be performed. 3. This product does not dissolve pigment stones, mixed stones, or radiopaque stones.
[Use in Children]
This study has not been conducted and no reliable references are available.
[Use in Elderly Patients]
Use with caution in elderly patients.
[Overdose]
In case of overdose, immediately perform gastric lavage with at least 1L of cholestyramine or activated charcoal (2g per 100mL of water), followed by oral administration of 50mL of aluminum hydroxide suspension.
[Pharmacology and Toxicology]
Pharmacological Action: This product increases bile acid secretion and alters bile acid composition, increasing its content in bile. It also significantly reduces the molar concentration of cholesterol and cholesterol esters and the cholesterol saturation index in human bile, thereby facilitating the gradual dissolution of cholesterol in stones. Toxicology: This study has not been conducted and no reliable references are available.
