Product Overview
[Drug Name]
Generic Name: Domperidone Tablets
Trade Name: Qianjin Xiangjiang/Beiyinshu Domperidone Tablets 10mg*30 Tablets
Pinyin Code: QianJinXiangJiang/BeiYinShu DuoPanLiTongPian 10mg*30 Tablets
[Main Ingredients]
Each tablet contains 10mg of domperidone. Excipients include pregelatinized starch, lactose, microcrystalline cellulose, sodium starch glycolate, magnesium stearate, micronized silica gel, and povidone.
[Properties]
White tablets.
[Indications/Main Functions]
Indicated for indigestion, abdominal distension, belching, nausea, vomiting, and abdominal pain.
[Specifications]
10mg*30 tablets
[Dosage and Administration]
Oral. Adults: 1 tablet three times daily, 15-30 minutes before meals.
[Adverse Reactions]
1. Occasionally, mild abdominal cramps, dry mouth, rash, headache, diarrhea, nervousness, fatigue, drowsiness, and dizziness may occur.
2. Occasionally, elevated serum prolactin levels, galactorrhea, and gynecomastia may occur, but these symptoms return to normal after discontinuation of the drug.
[Contraindications]
This product is contraindicated in patients with pheochromocytoma, breast cancer, mechanical intestinal obstruction, or gastrointestinal bleeding.
[Precautions]
1. Use with caution in pregnant women. Breastfeeding women should discontinue breastfeeding while using this product.
2. Domperidone suspension is not recommended for children.
3. Caution is advised when using this product in patients with heart disease (arrhythmias) or cancer patients undergoing chemotherapy, as it may aggravate heart rhythm disorders.
4. In case of overdose or serious adverse reactions, seek medical attention immediately.
5. This product is contraindicated in patients with allergies and should be used with caution in those with allergic constitutions.
6. This product should not be used if its properties change.
7. Keep out of reach of children. 8. If you are currently taking other medications, consult your physician or pharmacist before using this product.
9. This product contains lactose and may not be suitable for patients with lactose intolerance, galactosemia, or glucose/galactose malabsorption.
10. When taking this product with antacids or drugs that inhibit gastric acid secretion, these drugs should not be taken before meals but should be taken after meals. In other words, they should not be taken simultaneously with this product.
11. Because domperidone is primarily metabolized in the liver, it should be used with caution in patients with impaired liver function.
12. In patients with severe renal insufficiency (serum creatinine ≥6 mg/100 ml, i.e., ≥0.6 mmol/l), the elimination half-life of domperidone increases from 7.4 hours to 20.8 hours, but blood concentrations are lower than those in healthy volunteers. Because minimal unchanged drug is excreted through the kidneys, patients with renal insufficiency may not require dose adjustment after a single dose. However, if repeated dosing is necessary, the frequency should be reduced to once or twice daily depending on the severity of renal impairment. The dosage should be discussed with a physician or pharmacist. Long-term medication use in these patients requires regular monitoring.
[Drug Interactions]
1. This product should not be used concomitantly with azole antifungals such as ketoconazole and itraconazole, macrolide antibiotics such as erythromycin, HIV protease inhibitors, and nefazodone.
2. Anticholinergic drugs such as tadalafil, propantheline bromide, anisodamine, and belladonna tablets can weaken the effects of this product and should not be taken concomitantly.
3. Antacids and drugs that inhibit gastric acid secretion can reduce the bioavailability of this product and should not be taken concomitantly.
4. Concomitant use with other medications may result in drug interactions. Please consult a physician or pharmacist for details.
[Pharmacology and Toxicology]
This product acts directly on the gastrointestinal wall, increasing gastrointestinal motility and tone, promoting gastric emptying, increasing antral and duodenal motility, and coordinating pyloric contractions. It also enhances esophageal motility and lower esophageal sphincter tone, suppressing nausea and vomiting. This product does not readily cross the blood-brain barrier.
[Storage]
Store in a sealed container away from light.
[Packaging]
PVC rigid sheets, aluminum foil blister pack, 30 tablets/sheet x 1 sheet/box.
[Expiry Period]
24 months
[Approval Number]
National Medicine Standard H20093426
[Manufacturer]
Hunan Qianjin Xiangjiang Pharmaceutical Co., Ltd.
