Product Overview
[Drug name]
Generic name: Tamsulosin hydrochloride sustained-release capsules
Trade name: ZeSuoXin Tamsulosin hydrochloride sustained-release capsules 0.2mg*10 capsules*2 plates
Pinyin full code: ZeSuoXin YanSuanTanSuoLuoXinHuanShiJiaoNang 0.2mg*10Li*2Ban
[Main ingredients]
The main ingredient of this product is tamsulosin hydrochloride. Chemical name: (-)-(R)-5-[2-{[2-(o-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxyphenylsulfonamide hydrochloride Molecular formula: C20H28N2O5S·HCl
Molecular weight: 444.97
[Properties]
This product is a capsule, and the contents are off-white spherical particles.
[Indications/main functions]
Urinary disorders caused by prostatic hyperplasia.
[Specification]
0.2mg*10 tablets*2 plates
[Usage and Dosage]
Adults, once a day, one tablet (0.2mg) each time, orally after meals. The dosage may be increased or decreased according to age and symptoms.
[Adverse Reactions]
1. Serious adverse reactions: absence, loss of consciousness (frequency unknown): Because there may be transient loss of consciousness accompanied by a drop in blood pressure, the medication should be fully observed during use. If abnormal conditions occur, the medication should be discontinued and appropriate treatment measures should be taken. 2. Other adverse reactions: (1) Mental and nervous system: symptoms such as dizziness, headache, and staggering are occasionally seen. (2) Circulatory system: symptoms such as a drop in blood pressure, postural hypotension, increased heart rate, and palpitations are occasionally seen. (3) Allergic reactions: itching, rash, and urticaria may occasionally occur. If such symptoms occur, the medication should be discontinued. (4) Digestive system: nausea, vomiting, stomach discomfort, abdominal pain, loss of appetite, diarrhea, constipation, and difficulty swallowing are occasionally seen. (5) Liver function: GOT, GPT, and LDH are occasionally elevated. (6) Intraoperative Floppy Iris Syndrome: It has been reported that patients who are taking or have taken α1 receptor antagonists may experience intraoperative Floppy Iris Syndrome due to the α1 receptor antagonist effect. Ophthalmologists should pay attention to the occurrence of intraoperative Floppy Iris Syndrome when performing ophthalmic surgery. (7) Others: Occasionally, nasal congestion, epistaxis, edema, fatigue, priapism, ejaculation disorder, blurred vision, visual impairment, erythema multiforme, exfoliative dermatitis, etc.
[Contraindications]
This product is contraindicated for patients who are allergic to it.
[Precautions]
1. This product can be used after prostate cancer diagnosis is excluded. Because this product has the effect of relieving symptoms, it is recommended that patients be screened for other diseases that can cause symptoms similar to prostate hyperplasia, such as prostate cancer, before using tamsulosin for treatment, and screened regularly after tamsulosin treatment. 2. When taking antihypertensive drugs in combination, pay close attention to changes in blood pressure. 3. Be careful not to chew the particles in the capsule. 4. Use with caution in patients with postural hypotension and severe liver dysfunction. 5. No dose reduction is required in patients with renal insufficiency. Since it has not been studied in patients with severe renal dysfunction (creatinine clearance <10ml/min), such patients should use it with caution. 6. Because dizziness may occur, please be careful when working at heights or driving a car, which may be accompanied by dangerous work. 7. When tamsulosin is used in combination with strong inhibitors of CYP3A4 or CYP4D6 (e.g. ketoconazole, paroxetine), the exposure of tamsulosin may increase significantly. When used in combination with ketoconazole (CYO3A4 inhibitor), the Cmax and AUC of tamsulosin will increase by 2.2 and 2.8 times, respectively. When used in combination with paroxetine (CYP2D6 inhibitor), the Cmax and AUC of tamsulosin will increase by 1.3 and 1.6 times, respectively. 8. There have been reports of cases of allergic reactions in patients with a history of allergy to sulfonamides taking tamsulosin. Patients with a history of allergy to sulfonamides should take tamsulosin hydrochloride with caution.
