Product Overview
[Drug name]
Generic name: Compound Metronidazole Vaginal Suppository
Trade name: Kangyouni Compound Metronidazole Vaginal Suppository 0.45g*6 tablets
Pinyin full code: KangYouNi FuFangJiaXiaoZuoYinDaoShuan
[Main ingredients]
This product is a compound preparation, its components are: metronidazole 450mg, tetracycline 50mg, nystatin 30mg.
[Properties]
This product is a brown or brownish yellow torpedo-shaped suppository. This product is a white or slightly yellow suppository.
[Indications/Main functions]
Anti-trichomoniasis and antibiotic drugs, used to treat trichomonas vaginitis, fungal vaginitis, bacterial vaginitis and senile vaginitis, nonspecific vaginitis and mycoplasma infection, gonorrhea infection and other diseases.
[Specification]
0.45g*6 tablets (Kangyouni)
[Usage and Dosage]
For vaginal use, after menstruation is over, clean the vulva before going to bed every night, lie on your back, take one tablet and insert it deep into the vagina, once a day, for seven to ten days.
[Adverse Reactions]
Local adverse reactions are rare. Because this product can be absorbed from the mucous membrane, long-term and large-scale use can also produce the same adverse reactions as systemic medication: 1. It can cause epileptic seizures and peripheral neuropathy, the latter mainly manifested as numbness and paresthesia of the extremities. In some cases, long-term use of the drug can cause persistent peripheral neuropathy. 2. Other common adverse reactions include: (1) Gastrointestinal reactions, such as nausea, loss of appetite, vomiting, diarrhea, abdominal discomfort, taste changes, dry mouth, metallic taste in the mouth, etc. (2) Reversible neutropenia. (3) Allergic reactions, rash, urticaria, itching, etc. (4) Central nervous system symptoms, such as headache, dizziness, syncope, paresthesia, limb numbness, ataxia and mental confusion. (5) Other symptoms include elevated serum aminotransferase, fever, cystitis, dysuria, dark urine, etc., which are all reversible and will recover on their own after stopping the drug.
[Contraindications]
After large-scale use of this product, it can also produce drug interactions similar to systemic medications, such as inhibiting the metabolism of warfarin and other oral anticoagulants to prolong the prothrombin time, interfering with the metabolism of disulfiram and the results of serum aminotransferase and lactate dehydrogenase determination, and combining with liver microsomal enzyme inducers or inhibitors to accelerate or slow down the metabolism of this product in the liver.
[Drug Interactions]
After large-scale use of this product, it can also produce drug interactions similar to systemic medications, such as inhibiting the metabolism of warfarin and other oral anticoagulants to prolong the prothrombin time, interfering with the metabolism of disulfiram and the results of serum aminotransferase and lactate dehydrogenase determination, and combining with liver microsomal enzyme inducers or inhibitors to accelerate or slow down the metabolism of this product in the liver.
[Precautions]
1. Women with no sexual history should use this product under the guidance of a physician. 2. Avoid using this product during menstruation. 3. Wash your hands or wear gloves when administering the medicine. 4. Pay attention to personal hygiene during medication, prevent repeated infection, use condoms or avoid sexual intercourse. 5. If there is a burning sensation, redness or swelling at the medication site, stop taking the medicine and wash the local medicine. Consult a doctor if necessary. 6. It is forbidden for those who are allergic to this product, and it should be used with caution by those with allergic constitution. 7. It is forbidden to use this product when its properties change. 8. Please keep this product out of reach of children. 9. If you are using other medicines, please consult a doctor or pharmacist before using this product.
[Drugs for children]
Use with caution in children.
[Drugs for elderly patients]
Due to decreased liver function, the pharmacokinetics of this product are changed when the elderly use it, so it should be used with caution.
[Overdose]
It is not clear yet.
[Pharmacology and toxicology]
Metronidazole: Metronidazole has a strong antibacterial effect on most anaerobic bacteria, but has no effect on aerobic bacteria and facultative anaerobic bacteria. The antibacterial spectrum includes Bacteroides fragilis and other Bacteroides, Fusobacterium, Clostridium perfringens, Eubacterium, Veillonella, Peptococcus and Peptostreptococcus. Its bactericidal concentration is slightly higher than the inhibitory concentration. In addition, it also has a strong killing effect on amoeba and Trichomonas. The bactericidal mechanism of metronidazole has not been fully elucidated. The nitroreductase of anaerobic bacteria plays an important role in the energy metabolism of sensitive strains. The nitro reduction of this product is a cytotoxin, which acts on the DNA metabolism process of bacteria and promotes cell death. The mechanism of anti-amoeba is to inhibit its redox reaction and break the nitrogen chain of the protozoa. Ginseng stem and leaf saponins and vitamin E have the effect of promoting the healing of mucosal and skin wounds.
