Product Overview
[Drug Name]
Generic Name: Indapamide Extended-Release Tablets
Trade Name: Natali Extended-Release Tablets
English Name: Indapamide
Chinese Pinyin: Yindapa'an Huanshi Pian
[Ingredients]
Main Ingredient: The main ingredient of this product is indapamide, whose chemical name is N-(2-methyl-2,3-dihydro-1H-indolyl)-3-sulfamoyl-4-chloro-benzamide.
[Properties]
This product is a sugar-coated tablet that appears white after removal of the sugar coating.
[Indications]
For the treatment of hypertension. Primarily used for the treatment of mild to moderate hypertension, it is effective for renal hypertension and diabetic hypertension.
[Dosage and Administration]
Usual adult dose: Oral, 2.5 mg (1 tablet) once daily.
[Adverse Reactions]
Relatively mild and transient, and dose-related. 1. Less common reactions include: diarrhea, headache, decreased appetite, insomnia, nausea, and orthostatic hypotension. 2. Rare reactions include: allergic reactions such as rash and itching; hyponatremia, hypokalemia, and hypochloremic alkalosis.
[Contraindications]
Sulfonamide allergy, severe renal insufficiency, hepatic encephalopathy or severe hepatic insufficiency, and hypokalemia.
[Precautions]
1. To reduce the possibility of electrolyte imbalance, a smaller effective dose should be used. Serum potassium, sodium, and uric acid levels should be monitored regularly to maintain fluid and electrolyte balance and ensure timely potassium supplementation. 2. When used as a diuretic, it is best to administer the drug once a day in the morning to avoid having to urinate at night. 3. Anuria or severe renal insufficiency may induce azotemia. 4. Glucose tolerance may be impaired in diabetes. 5. Gout or hyperuricemia may further increase serum uric acid. 6. In hepatic insufficiency, diuresis may precipitate hepatic coma. 7. After sympathectomy, the antihypertensive effect may be enhanced. 8. If surgery is required while taking this drug, it is not necessary to discontinue use, but the anesthesiologist must be informed.
[Use in Special Populations]
Precautions for Children:
There is a lack of research data on the use of this drug in pediatric patients.
Precautions for Pregnancy and Lactation:
During Pregnancy: Diuretics can cause placental atrophy and lead to fetal malnutrition. As a general rule, pregnant women should avoid the use of thiazide and related diuretics, and they should never be used to treat physiologic edema of pregnancy. During Lactation, because the drug may enter breast milk, lactating women should avoid taking this drug.
Precautions for Elderly:
See [Precautions].
[Drug Interactions]
1. The diuretic and natriuretic effects of this drug are weakened when used concomitantly with corticosteroids. 2. The concomitant use of this drug with amiodarone may predispose to arrhythmias due to low serum potassium. 3. The anticoagulant effect of this drug is weakened when used concomitantly with oral anticoagulants. 4. The natriuretic effect of this drug is weakened when used concomitantly with nonsteroidal anti-inflammatory analgesics. 5. The diuretic effect of this drug is enhanced when used concomitantly with dopamine. 6. This product's antihypertensive effect is enhanced when used concomitantly with other antihypertensive drugs. 7. This product's antihypertensive effect is weakened when used concomitantly with sympathomimetics. 8. This product may increase blood lithium concentrations and cause signs of overdose when used concomitantly with lithium. 9. When used concomitantly with high doses of salicylates, dehydrated patients may develop acute renal failure. 10. Concomitant use with metformin may cause lactic acidosis.
[Pharmacological Action]
This is a sulfonamide diuretic that acts by inhibiting water and electrolyte reabsorption in the dilute segment of the distal renal tubular cortex. Its antihypertensive mechanism is unclear, and its diuretic effect cannot explain its antihypertensive effect because the dose at which it occurs is much lower than the dose at which it would otherwise have a diuretic effect. Possible mechanisms include: regulating calcium influx into vascular smooth muscle cells; stimulating the synthesis of prostaglandins PGE2 and PGI2; and reducing vascular hypersensitivity to vasopressors, thereby inhibiting vasoconstriction. This product has little or no effect on cardiac output, heart rate, or rhythm when used to lower blood pressure. Long-term use of this drug rarely affects glomerular filtration rate or renal blood flow. It does not affect lipid and carbohydrate metabolism.
[Storage] Store in a dark, sealed container.
[Specification] 1.5mg x 10 tablets
[Packaging] Box
[Expiry Date] 36 months
[Approval Number] National Medicine Standard H20031281
[Manufacturer] Servier (Tianjin) Pharmaceutical Co., Ltd.
