Product Overview
[Drug Name]
Generic Name: Trospium Chloride Capsules
Trade Name: Heshou Trospium Chloride Capsules 20mg*10 Capsules
Pinyin Full Code: HeShou QuSiLvZuoJiaoNang 20mg*10Li
[Main Ingredient]
The main ingredient and its chemical name are: 3-benziloylnorhyroxy-8-spiro-1-pyrrolidine chloride.
[Indications/Main Functions]
Used to treat urinary frequency, urgency, and urge incontinence caused by detrusor instability or detrusor hyperreflexia.
[Specifications]
20mg*10 Capsules
[Dosage and Administration]
Oral, one tablet twice daily (equivalent to 40mg daily). Or as directed by a physician. The recommended dose for patients with severe renal insufficiency (creatinine clearance 10-30 ml/min/1.73 m2) is one tablet daily or every other day (i.e., 20mg daily or every other day). Take the entire tablet with water on an empty stomach before meals. The duration of treatment should be determined by the physician. Continuation of treatment should be determined by the physician during regular follow-up visits every 3-6 months.
[Adverse Reactions]
Common adverse reactions include dry mouth and constipation.
[Contraindications]
1. Contraindicated in patients with allergies to this drug or its ingredients. 2. Contraindicated in patients with urinary retention, gastric retention, and uncontrolled angle-closure glaucoma.
[Precautions]
Unknown.
[Pharmacology and Toxicology]
This drug is a synthetic tropic acid with four ammonium groups. It is a parasympathetic blocker with similar effects to atropine. It primarily acts by competitively binding to the endogenous neurotransmitter acetylcholine at postsynaptic M-receptors. It reduces parasympathetic tone and relieves smooth muscle spasms caused by parasympathetic nerves in organs innervated by the parasympathetic nervous system. It also has certain effects on the gastrointestinal, biliary, and urinary tracts. This product has low lipid solubility and is difficult to cross the blood-brain barrier, resulting in no central nervous system side effects. Acute and chronic toxicity studies in two rodent species demonstrated that observed side effects were due to enhanced pharmacological activity, rather than specific target organ toxicity, and that there were no sex differences. It exhibited no reproductive toxicity at the maximum tolerated dose, and in vitro and in vivo studies demonstrated no mutagenic or carcinogenic effects.
