Product Overview
[Drug Name]
Generic Name: Enalapril Maleate Tablets
Trade Name: Shuanghe Pharmaceutical Enalapril Maleate Tablets 10mg*16 Tablets
Pinyin Code: ShuangHeYaoYe MalaiSuanYiNaPuLi Tablets 10mg*16 Tablets
[Main Ingredients]
The main ingredient of this product is: Enalapril Maleate. [Ingredient] Chemical Name: N-{(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanyl-L-proline maleate Molecular Formula:
C20H28N2O5.C4H4O4 Molecular Weight: 492.52
[Properties]
This product is white or off-white tablets.
[Indications/Main Functions]
This drug can be used in combination with diuretics and digitalis for patients with hypertensive heart failure, especially those with severe heart failure.
[Specifications]
10mg x 16 tablets
[Dosage and Administration]
The initial dose is 5-10mg daily, divided orally into 1-2 doses. For patients with severely impaired renal function (creatinine clearance less than 30ml/min), the daily dose is 2.5mg. The dose can be gradually increased depending on blood pressure levels. The generally effective dose is 10-20mg daily. The maximum daily dose should generally not exceed 40mg. It can be used in combination with other antihypertensive drugs, especially diuretics, to significantly enhance the antihypertensive effect. However, it should not be used in combination with porcine potassium diuretics.
[Adverse Reactions]
May include dizziness, headache, drowsiness, dry mouth, fatigue, upper abdominal discomfort, nausea, chest tightness, cough, rash, flushing, and proteinuria. Reduce the dose as necessary. Discontinue the drug if leukopenia occurs.
[Contraindications]
1. Contraindicated in patients with allergies to this product or bilateral renal artery stenosis. Use with caution in children, pregnant women, lactating women, and patients with severe renal impairment. 2. Contraindicated in patients with allergies to this product or its ingredients.
[Drug Interactions]
Drug interactions may occur if used concomitantly with other medications. Please consult your physician or pharmacist for details.
[Precautions]
1. Some patients, especially those taking diuretics or experiencing hypovolemia, may experience an excessive drop in blood pressure. Therefore, the initial dose should be 2.5 mg. 2. Regularly monitor white blood cell counts, renal function, and serum potassium.
[Pediatric Use]
Use with caution in children.
[Elderly Use]
Unclear information available.
[Overdose]
Unclear information available.
[Pharmacology and Toxicology]
Angiotensin-converting enzyme inhibitor. After oral administration, it is hydrolyzed in the body to enalaprilat, which strongly inhibits angiotensin-converting enzyme (ACE), reducing angiotensin I levels, causing systemic vasodilation and lowering blood pressure. It has a significant antihypertensive effect in rat models of diuretic and monorenal hypertension, as well as spontaneous hypertension.
