Product Overview
[Drug Name]
Generic Name: Domperidone Tablets
Trade Name: Tianping Domperidone Tablets, 10mg x 30 Tablets
Pinyin Full Code: DuoPanLiTongPian
[Main Ingredients]
The main ingredient of this product is: Domperidone. Chemical Name: 5-chloro-1-[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidinyl]-2-benzimidazolinone. Molecular Formula: C₂₂H₂₄ClN₅O₂. Molecular Weight: 425.9
[Properties]
This product is a white tablet.
[Indications/Main Functions]
1. Relieves symptoms of indigestion caused by delayed gastric emptying, gastrointestinal reflux, and esophagitis, such as upper abdominal fullness, bloating, upper abdominal pain, belching, flatulence, and burning sensation in the mouth with or without refluxed gastric contents. 2. For the treatment of nausea and vomiting caused by functional, organic, infectious, dietary, radiotherapy, or chemotherapy.
[Specifications]
10mg x 30 tablets (Tianping)
[Dosage and Administration]
Oral:
1. Adults: 10mg 3-4 times daily. The dose may be doubled if necessary or as directed by a physician.
2. Children: 0.3mg per kg of body weight 3-4 times daily. This product should be taken 15-30 minutes before meals.
[Adverse Reactions]
1. Occasionally, transient, mild abdominal cramping may occur.
2. Serum prolactin levels may sometimes increase, but return to normal after discontinuation of the drug. This effect is similar to that seen with many other drugs.
[Contraindications]
Not yet known.
[Precautions]
1. This product is contraindicated in patients with allergies.
2. This product is contraindicated in patients with pheochromocytoma, breast cancer, mechanical intestinal obstruction, gastrointestinal bleeding, and other conditions.
3. Domperidone suspension is not recommended for children.
4. Use with caution in pregnant women.
5. Caution is advised when using this product in patients with heart disease (cardiac arrhythmias) or cancer patients undergoing chemotherapy, as it may worsen heart rhythm disturbances.
6. In case of overdose or serious adverse reactions, seek medical attention immediately.
7. Do not use if the drug's properties change.
8. Keep this product out of reach of children.
[Drug Interactions]
Anticholinergic drugs may antagonize the anti-dyspeptic effects of this product; therefore, these drugs should not be used together.
[Pediatric Use]
Due to the immature development of the blood-cerebrospinal fluid barrier in children under one year of age, the possibility of central nervous system side effects cannot be ruled out.
[Elderly Use]
The potential for this product is unknown.
[Pregnant and Breastfeeding Use]
Use with caution in pregnant women.
[Overdose]
The potential for this product is unknown.
[Pharmacology and Toxicology]
This drug is a peripheral dopamine receptor blocker that acts directly on the gastrointestinal wall. It increases lower esophageal sphincter tone, prevents gastroesophageal reflux, enhances gastric motility, promotes gastric emptying, coordinates gastric and duodenal motility, inhibits nausea and vomiting, and effectively prevents bile reflux without affecting gastric secretion. It does not readily cross the blood-cerebrospinal fluid barrier and has no inhibitory effect on dopamine receptors in the brain. Therefore, it is not associated with extrapyramidal or other neurological or psychiatric adverse reactions.
[Pharmacokinetics]
After oral administration, it is rapidly absorbed, reaching peak plasma concentrations within 15-30 minutes. Distribution is highest in the gastrointestinal tract, followed by plasma, with virtually no drug present in the brain. This drug is almost entirely metabolized in the liver, with a half-life (t½) of 7 hours. Urinary excretion accounts for 31.23%, with unchanged drug accounting for 0.4%. Fecal excretion accounts for 65.7%, with unchanged drug accounting for 10%.
[Storage]
Store in a sealed container away from light.
[Packaging]
Aluminum-plastic blister pack, 20 tablets/box.
[Expiration Period]
36 months
[Approval Number]
National Medicine Standard H20031280
[Manufacturer]
Shanghai Xinyi Tianping Pharmaceutical Co., Ltd.
