Product Overview
[Drug Name]
Trade Name: Aoke
English Name: Omeprazole Enteric Capsules
Chinese Pinyin: Aomeilazuo Jiaonang
[Main Ingredients]
The main ingredient of this product is omeprazole.
[Properties]
Capsules containing small granules coated with an off-white enteric coating.
[Indications]
Indicated for gastric ulcers, duodenal ulcers, stress ulcers, reflux esophagitis, and Zollinger-Ellison syndrome (gastrinoma).
[Dosage and Administration]
Oral administration; do not chew.
1. Peptic ulcer: 20 mg (1 tablet at a time), 1-2 times daily. Take once in the morning or once in the morning and evening. The treatment course for gastric ulcers is usually 4-8 weeks, and for duodenal ulcers, 2-4 weeks.
2. Reflux esophagitis: 20-60 mg (1-3 tablets at a time), 1-2 times daily. Take once in the morning or once in the morning and evening. The course of treatment is usually 4 to 8 weeks.
3. Zollinger-Ellison syndrome: Take 60 mg (3 tablets at a time) once daily. The total daily dose can be adjusted to 20 to 120 mg (1 to 6 tablets) depending on the condition. If the total daily dose exceeds 80 mg (4 tablets), it should be taken in two divided doses.
[Adverse Reactions]
This product is well tolerated. Common adverse reactions include diarrhea, headache, nausea, abdominal pain, gastrointestinal flatulence, and constipation. Occasionally, elevated serum aminotransferases (ALT, AST), rash, dizziness, drowsiness, and insomnia may occur. These adverse reactions are generally mild, resolve spontaneously, and are unrelated to dose. No serious adverse reactions have been observed with long-term treatment, but gastric mucosal cell hyperplasia and atrophic gastritis may occur in some cases.
[Contraindications]
This product is contraindicated in patients with allergies, severe renal insufficiency, and infants and young children.
[Precautions]
1. When treating gastric ulcers, the possibility of ulcer-type gastric cancer should be ruled out first, as this product may alleviate symptoms and thus delay treatment.
2. Use with caution in patients with hepatic and renal insufficiency.
3. This product comes in enteric-coated capsules; be careful not to chew them when taking to prevent premature release of the drug in the stomach, which could affect efficacy.
[Special Population Use]
Precautions for Children: Contraindicated in infants and young children.
Precautions for Pregnancy and Lactation: Although this product has not been shown to cause teratogenicity in animal studies, it should generally not be used in pregnant women and should be used with caution in lactating women.
Precautions for the Elderly: Not yet known.
[Drug Interactions]
This product may delay the elimination of drugs metabolized by the liver, such as diazepam, phenytoin, warfarin, and nifedipine. When used with these drugs, the dosage of the latter should be reduced.
[Pharmacological Actions]
Proton pump inhibitor. This drug is a fat-soluble, weakly alkaline drug that is easily concentrated in acidic environments. Therefore, after oral administration, it is specifically distributed in the secretory tubules of the gastric parietal cells. In this highly acidic environment, it is converted into its active form, the sulfenamide. It then irreversibly binds to the sulfhydryl group of the H+, K+-ATPase (also known as the proton pump) in the secretory membrane of the parietal cells via a disulfide bond, forming a sulfenamide-proton pump complex. This inhibits the enzyme's activity and blocks the final step of gastric acid secretion. Therefore, this drug has a strong and long-lasting inhibitory effect on gastric acid secretion caused by various causes.
[Storage]
Store in a dry, airtight container protected from light.
[Specifications]
20mg x 14 tablets
[Packaging Size]
Box
[Expiry Period]
24 months.
[Approval Number]
National Medicine Standard No. H10950086
[Manufacturer]
Company Name: Changzhou Siyao Pharmaceutical Co., Ltd.
