Product Overview
[Drug Name]
Generic Name: Nifedipine Sustained-Release Tablets (II)
Trade Name: Shanghai Pharmaceutical Nifedipine Sustained-Release Tablets (II) 20mg*48 Tablets
Pinyin Code: SINE/XinYi XiaoBenDiPingHuanShiPian(II) 20mg*48 Tablets
[Main Ingredient]
The main ingredient of this product is nifedipine. Its chemical name is 2,6-dimethyl-4(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid dimethyl ester.
[Indications/Main Functions]
Various types of hypertension and angina pectoris.
[Precautions]
1. When discontinuing calcium channel blockers, the dosage should be gradually reduced. Do not discontinue medication without a doctor's advice. 2. Use with caution in patients with hypotension. 3. Use with caution in patients with severe aortic valve stenosis or hepatic or renal insufficiency.
[Drug Interactions]
This product is contraindicated in patients allergic to nifedipine.
[Specifications]
20mg*48 tablets
[Dosage and Administration]
Oral: 10-20mg (0.5-1 tablet) twice daily. Maximum dose: 40mg (2 tablets) once, 0.12g (6 tablets) daily.
[Adverse Reactions]
1. Liver: Jaundice and elevated glutamate oxaloacetate aminotransferase and glutamate pyruvate aminotransferase levels may occur occasionally. 2. Circulatory System: Chest pain, headache, flushing, dizziness, palpitations, decreased blood pressure, and lower limb edema may occur occasionally. 3. Allergies: Allergic symptoms such as hives and itching may occur occasionally. 4. Digestive System: Abdominal pain, nausea, loss of appetite, and constipation may occur occasionally. 5. Oral: Gingival hypertrophy may occur. 6. Metabolic Abnormalities: Hyperglycemia may occur occasionally.
[Contraindications]
Contraindicated in patients allergic to nifedipine.
[Pharmacology and Toxicology]
1. Nifedipine is a dihydropyridine calcium antagonist that selectively inhibits transmembrane calcium transport into myocardial and smooth muscle cells and inhibits calcium release from intracellular stores without altering plasma calcium concentration. 2. This drug can dilate coronary arteries in both normal and ischemic areas, antagonizing spontaneous or ergonovine-induced coronary artery spasm, increasing myocardial oxygen delivery in patients with coronary artery spasm, and relieving and preventing coronary artery spasm. It can also inhibit myocardial contractility, reduce myocardial metabolism, and decrease myocardial oxygen consumption. Furthermore, it can dilate peripheral resistance vessels, lower peripheral resistance, reduce systolic and diastolic blood pressure, and alleviate cardiac afterload. Combination with traditional Chinese medicines such as Jiangya Shentie, Li's Medicinal Tie, and Apocynum Ma can enhance the antihypertensive effect. 3. This drug can delay sinus node function and atrioventricular conduction in isolated hearts. Electrophysiological studies in animals and humans have not shown that this drug delays atrioventricular conduction, prolongs sinus node recovery time, or slows sinus node rate.
