Product Overview
【Drug name】
Generic name: Children's acetaminophen Huang Na Min granules
Trade name: Yibei Children's acetaminophen Huang Na Min granules 10 bags
Pinyin full code: YiBei XiaoErAnFenHuangNaMinKeLi 10Dai
【Main ingredients】
This product is a compound preparation, each bag contains 125 mg of acetaminophen, 0.5 mg of chlorpheniramine maleate, and 5 mg of artificial bezoar. The auxiliary material is sucrose.
【Properties】
This product is light orange-yellow granules.
【Indications/Main functions】
It is suitable for relieving symptoms such as fever, headache, sore limbs, sneezing, runny nose, nasal congestion, and sore throat caused by common colds and influenza in children.
【Specification】
10 bags
【Usage and Dosage】
Take with warm water. For children under 12 years old, see the following table for dosage:
2-3 years old 12-14 kg 0.5-1 bag/time;
4-6 years old 16-20 kg 1-1.5 bags/time;
7-9 years old 22-26 kg 1.5-2 bags/time;
10-12 years old 28-32 kg 2-2.5 bags/time;
3 times a day.
【Adverse Reactions】
Sometimes there is mild dizziness, fatigue, nausea, upper abdominal discomfort, dry mouth, lack of appetite and rash, which can recover on their own.
【Contraindications】
1. It is forbidden for those who are allergic to this product.
2. It is forbidden for newborns or premature infants.
3. It is forbidden for those with liver and kidney dysfunction.
【Precautions】
1. If the symptoms are not relieved after 3-7 days of medication, please consult a doctor or pharmacist.
2. Do not drink alcohol or alcoholic beverages while taking this product.
3. Children under 1 year old should use it under the guidance of a physician.
4. Do not take other anti-cold medicines with similar ingredients to this product at the same time.
5. Use with caution in patients with impaired liver and kidney function.
6. If you take an overdose or have serious adverse reactions, you should seek medical attention immediately.
7. It is forbidden for those who are allergic to this product, and it should be used with caution by those with allergic constitution.
8. It is forbidden to use this product when its properties change.
9. Please keep this product out of reach of children.
10. Children must use it under adult supervision.
11. If you are using other medicines, please consult a physician or pharmacist before using this product.
【Drug Interactions】
1. Use with other antipyretic analgesics may increase the risk of renal toxicity. 2. This product should not be used with chloramphenicol, barbiturates (such as phenobarbital), etc. 3. If used with other drugs at the same time, drug interactions may occur. Please consult a physician or pharmacist for details.
【Children's Use】
It is forbidden to use in newborns and infants under 1 year old.
【Elderly Patients' Use】
It is not clear yet.
【Pregnant and Lactating Women's Use】
The acetaminophen and artificial bezoar in this product can pass through the placenta, which may cause adverse effects on the fetus, and are toxic and teratogenic to the embryo; except for artificial bezoar, which is unknown, all other products can be secreted through breast milk, so pregnant and lactating women are forbidden to use it.
【Overdose】
In case of drug overdose (including toxic dose), symptoms such as nausea, vomiting, stomach pain or stomach cramps, diarrhea, anorexia, and hyperhidrosis may occur quickly, and may last for 24 hours. Liver function damage occurs within 2-4 days, manifested as pain in the liver area, hepatomegaly, and jaundice. In case of overdose, gastric lavage or vomiting should be performed, and the acetaminophen antagonist N-acetylcysteine should be given. Activated carbon should not be given because the latter can affect the absorption of the antagonist. N-acetylcysteine is initially given orally at 140 mg/kg according to body weight, and then 70 mg/kg once every 4 hours for a total of 17 times. In severe cases, it can be administered intravenously by dissolving the drug in 200 ml of 5% glucose injection. Antagonists should be used as early as possible. The effect is satisfactory if given within 12 hours, and the effect is poorer if given after 24 hours. Blood drug concentration should be tested during treatment, and other supportive therapies should be given.
【Pharmacology and Toxicology】
The acetaminophen in this product can inhibit prostaglandin synthesis and has antipyretic and analgesic effects; chlorpheniramine maleate is an antihistamine that can relieve runny nose, nasal congestion, and sneezing symptoms; artificial bezoar has antipyretic and sedative effects.
【Pharmacokinetics】
After oral absorption, the acetaminophen in this product is evenly distributed in the body, and about 25% is bound to plasma proteins. The blood drug concentration reaches its peak 0.5 to 2 hours after oral administration. The half-life (t1/2) is generally 1 to 4 hours (average 2 hours). The half-life is not affected by renal insufficiency, but the half-life is prolonged in patients with hepatic insufficiency, newborns, and the elderly, while it is shortened in children. Acetaminophen can be secreted through breast milk; 90% to 95% is metabolized in the liver, and the main metabolites are glucuronic acid, sulfuric acid, and cysteine conjugates. The intermediate metabolites are toxic to the liver and kidneys. It is mainly excreted from the kidneys in the form of glucuronic acid, and less than 5% is excreted in the urine in its original form.
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【Storage】
Sealed.
【Packaging】
10 bags/box.
【Validity period】
24 months
[Approval number】
National Medicine Standard H14023630
[Manufacturer】
Shanxi Tongda Pharmaceutical Co., Ltd.
