Product Overview
【Drug name】
Generic name: Shuangzuotai suppository
Trade name: Yanting Shuangzuotai suppository 7 pieces
Pinyin full code: DongXin ShuangZuoTaiShuan
【Main ingredients】
This product is a compound preparation, and its components are: each piece contains metronidazole, clotrimazole, and chlorhexidine acetate.
【Properties】
This product is a milky yellow duckbill or bullet-shaped suppository.
【Indications/Main functions】
It is used for bacterial vaginosis, candidal vulvovaginal disease, trichomoniasis vaginitis, and mixed bacterial, fungal, and trichomonas infection vaginitis.
【Specifications】
7 pieces (Yanting)
【Usage and dosage】
Vaginal administration. 1 piece at a time, once a night, and 7 consecutive days as a course of treatment.
【Adverse reactions】
Occasionally, rash, vaginal burning sensation, itching or other mucosal irritation symptoms may occur. Because this product can be absorbed from the mucosa, long-term and large-scale use can also produce the same adverse reactions as systemic medication:
1. It can cause epileptic seizures and peripheral neuropathy, the latter of which is mainly manifested as numbness and paresthesia of the extremities. In some cases, long-term use of the drug can cause persistent peripheral neuropathy.
2. Other common adverse reactions include:
(1) Gastrointestinal reactions, such as nausea, loss of appetite, vomiting, diarrhea, abdominal discomfort, taste changes, dry mouth, metallic taste in the mouth, etc.
(2) Reversible neutropenia.
(3) Allergic reactions, such as rash, urticaria, itching, etc.
(4) Central nervous system symptoms, such as headache, dizziness, syncope, paresthesia, limb numbness, ataxia and mental confusion, etc.
(5) Other symptoms include elevated serum aminotransferase, fever, cystitis, dysuria, dark urine color, etc., which are all reversible and will recover on their own after stopping the drug.
【Contraindications】
1. Patients who are allergic to this product or pyrrole (imidazole) drugs and patients with active central nervous system diseases and blood diseases are prohibited from using it.
2. Pregnant women are prohibited from using it.
【Precautions】
1. Bisoxazolidinone suppositories are only for vaginal administration and should not be taken orally.
2. Avoid using Bisoxazolidinone suppositories during menstruation.
3. Women with no sexual history should use it under the guidance of a physician.
4. If there is a burning sensation, redness or swelling at the medication site, stop taking the medication and wash the local medication off. Consult a physician if necessary.
5. Wash your hands or wear cots or gloves when administering the medication.
6. Pay attention to personal hygiene during medication to prevent repeated infection, use condoms or avoid sexual intercourse.
7. Lactating women should stop breastfeeding when using Bisoxazolidinone suppositories.
8. Elderly people should use it with caution.
9. If allergic symptoms or adverse reactions of the central nervous system occur during use, stop taking the medication immediately.
10. Use with caution in patients with liver and kidney dysfunction.
11. When treating vaginal trichomoniasis, the sexual partner should be treated at the same time.
12. Do not drink alcohol or beverages containing alcohol during the use of chlorhexidine suppositories.
13. Patients who are allergic to chlorhexidine suppositories are prohibited from using chlorhexidine suppositories. Patients with allergic constitutions should use it with caution.
14. Patients who change the properties of chlorhexidine suppositories are prohibited from using chlorhexidine suppositories.
15. Please keep chlorhexidine suppositories out of reach of children.
【Drug Interactions】
1. Chlorhexidine is incompatible with soap, potassium iodide, etc. It is also incompatible with borax, bicarbonate, carbonate, oxide, citrate, phosphate and sulfate. 2. When this product is used in combination with oxytetracycline, the latter may interfere with the effect of metronidazole in eliminating vaginal trichomoniasis. 3. Long-term and large-scale use, after absorption through the mucosa, may also produce drug interactions similar to systemic medication, such as inhibiting the metabolism of warfarin and other oral anticoagulants, interfering with disulfiram metabolism and serum aminotransferase and lactate dehydrogenase assay results, and co-administered with liver microsomal enzyme inducers or inhibitors, which can accelerate or slow down the metabolism of this product in the liver.
【Drug use in children】
Children should use with caution.
【Drug use in elderly patients】
Due to decreased liver function, the pharmacokinetics of this product are changed when the elderly use it, so it should be used with caution.
【Drug use in pregnant women and lactating women]
Animal experiments have found that metronidazole and clotrimazole are toxic to the fetus after intraperitoneal or oral administration. However, there is currently a lack of sufficient and rigorous controlled studies on pregnant and lactating women. Therefore, pregnant women are prohibited from using this product, and lactating women should stop breastfeeding when using this product.
【Drug overdose】
It is not clear yet.
【Pharmacology and toxicology】
This product is an antibacterial drug. Chlorhexidine is a broad-spectrum bactericide; clotrimazole is an antifungal drug; metronidazole has anti-anaerobic and anti-trichomonal effects.
【Pharmacokinetics】
This product is a topical drug, partially absorbed through the mucosa. The absorption of metronidazole and clotrimazole is approximately 20% to 25% and 3% to 10% of the administered dose, respectively, and the absorption of chlorhexidine acetate is very small. After absorption, metronidazole is widely distributed in various tissues and body fluids, and can pass through the blood-cerebrospinal fluid barrier. 60% to 80% is excreted through the kidneys, of which 20% is the original form and the rest is metabolites. A small part is excreted with feces or from the skin. After absorption, clotrimazole is metabolized into inactive metabolites in the liver and excreted with feces and urine.
【Storage】
Light-proof, sealed, at 30℃
【Validity period】
36 months
【Approval number】
National Medicine Standard H10983180
【Manufacturer】
Hubei Dongxin Pharmaceutical Co., Ltd.
