Product Overview
[Drug Name]
Generic Name: Bicyclol Tablets
Trade Name: Bisino
English Name: Bicyclol Tablets
Chinese Pinyin: Shuanghuanchun Pian
[Ingredients]
The main ingredient of this product is bicyclol.
[Properties]
This product is a white tablet.
[Indications]
This product is indicated for the treatment of elevated aminotransferases due to chronic hepatitis.
[Dosage and Administration]
For oral administration, the usual adult dose is 25 mg (1 tablet) per dose, which can be increased to 50 mg (2 tablets) three times daily. The dosage should be gradually reduced after a minimum of 6 months or as directed by a physician.
[Adverse Reactions]
Some patients may experience adverse reactions after taking this drug, which are mild or moderate. These reactions generally resolve without discontinuation of the drug, or with a short-term discontinuation of the drug, or with symptomatic treatment. No serious adverse reactions were observed in the 1,416 clinical studies. Occasionally (incidence 0.5%), dizziness, rash, abdominal distension, sleep disturbances, abnormal hemoglobin and white blood cell counts, elevated total bilirubin and transaminases, and decreased platelets were observed. In rare cases (incidence 0.1%), headache, nausea, stomach discomfort, and transient increases in blood glucose and blood creatinine were reported. Appropriate measures may be taken based on the specific clinical situation.
[Contraindications]
This product is contraindicated in patients with allergies to it or its other ingredients.
[Precautions]
1. Closely monitor the patient's clinical symptoms, signs, and changes in liver function during treatment, and follow up after the end of treatment. 2. Patients with liver decompensation, such as significantly elevated bilirubin, hypoalbuminemia, ascites due to cirrhosis, esophageal variceal bleeding, hepatic encephalopathy, severe organic heart, brain, or kidney diseases, and bone marrow suppression, should follow their physician's advice.
[Use in Special Populations]
Precautions for Children:
The optimal dosage for children under 12 years of age should be followed according to the physician's advice.
Precautions During Pregnancy and Lactation:
There are no studies on the effects of this drug on pregnant and lactating women. As with other medications, the benefits and risks should be weighed and caution should be exercised.
Precautions for Elderly Patients:
The optimal dosage for patients over 70 years of age remains to be determined.
[Drug Interactions]
There are no studies on interactions with other drugs.
[Pharmacological Actions]
Bicyclol is a biphenyl derivative. Animal studies have shown that bicyclol reduces the elevation of aminotransferases in mice with acute liver injury induced by carbon tetrachloride, D-galactosamine, and paracetamol, and in mice with immune-induced hepatitis, alleviating liver histopathological lesions to varying degrees. In vitro studies have shown that bicyclol inhibits the secretion of HBeAg, HBV DNA, and HBsAg in the 2.2.15 hepatoma cell line transfected with human hepatitis B virus.
[Storage] Store in sealed containers.
[Specifications] 25mg x 9 tablets
[Packaging] Box
[Expiration Period] 36 months
[Approval Number] National Medicine Standard H20040467
[Manufacturer] Peking Union Medical College Pharmaceutical Factory
