Product Overview
[Drug Name]
Generic Name: Dipyridamole Tablets
Trade Name: Yabao
English Name: Dipyridamole Tablets
Chinese Pinyin: Shuangmidamo Pian
[Ingredients]
Chemical Name: (2,2,2,2-[4,8-dipiperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl]bis(nitro)-tetraethanol)
[Properties]
Film-coated tablets.
[Indications]
For thromboembolic diseases and ischemic heart disease.
[Dosage and Administration]
Oral administration: 25-50 mg three times daily before meals. Or as directed by a physician.
[Adverse Reactions]
At therapeutic doses, adverse reactions are mild and transient. Initial side effects generally disappear with long-term use. Common adverse reactions include dizziness, headache, vomiting, diarrhea, flushing, rash, and itching. Angina and hepatic insufficiency are rare. Persistent or intolerable adverse reactions are rare and resolve after discontinuation of the drug. Post-marketing experience reports of rare adverse reactions include laryngeal edema, fatigue, discomfort, myalgia, arthritis, nausea, indigestion, paresthesia, hepatitis, alopecia, cholelithiasis, palpitations, and tachycardia.
[Contraindications]
This medication is contraindicated in patients with allergies.
[Precautions]
1. This medication may cause peripheral vasodilation; therefore, it should be used with caution in patients with hypotension.
2. It should not be mixed with other medications other than glucose for injection.
3. Concomitant use with heparin may cause bleeding diathesis.
4. Use with caution in patients with bleeding diathesis.
[Precautions for Use in Special Populations]
Precautions for Children:
The safety and efficacy of this medication have not been established in children under 12 years of age.
Precautions for Pregnancy and Lactation:
This medication has not been tested and no reliable references are available.
Precautions for Elderly Patients:
This medication has not been tested and no reliable references are available.
[Drug Interactions]
1. It has a synergistic effect with aspirin. When used concomitantly with aspirin, the dose should be reduced to 100-200 mg per day.
2. This product does not increase or exacerbate bleeding when used concomitantly with dicoumarol anticoagulants.
[Pharmacological Actions]
Dipyridamole has antithrombotic effects. It inhibits platelet aggregation and, at high concentrations (50 μg/ml), can inhibit platelet release. Possible mechanisms of action include: 1. Inhibition of adenosine uptake by erythrocytes, which is a platelet inhibitor; 2. Inhibition of phosphodiesterase, which increases cyclic adenosine monophosphate (cAMP) in platelets; 3. Inhibition of thromboxane A2 (TXA2) formation, which is a potent agonist of platelet activity; and 4. Enhancement of endogenous progesterone phosphatidylcholine (PGI2). Dipyridamole has a vasodilatory effect in dogs. Intraduodenal administration of dipyridamole at 0.5-4.0 mg/kg produces a dose-related decrease in systemic and coronary vascular resistance, lowering systemic blood pressure and increasing coronary blood flow. The onset of action is 24 minutes after administration, and the effects persist for approximately 3 hours. Similar effects are observed after intravenous administration of 0.025-2.0 mg/kg.
[Storage] Store in a sealed container in the dark.
[Strength] 25mg
[Packaging] 25mg x 100s
[Expiration] 36 months
[Approval Number] National Medicine Standard H14020968
[Manufacturer] Company Name: Yabao Pharmaceutical Group Co., Ltd.
