Product Overview
[Drug Name]
Generic Name: Mosapride Citrate Tablets
Trade Name: Yabao Shuan
English Name: Mosapride Citrate Tablets
Chinese Pinyin: ZuoZuoSuanMoShaBiLiPian (YaBaoShuAn)
[Ingredients]
The main ingredient of this product is mosapride citrate. Its chemical name is: 4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)-2-morpholinyl]methyl}benzamide citrate. Molecular formula: C21H25ClFN3O3C6H8O72H2O
[Properties]
This product is white or off-white tablets.
[Indications]
This product is a gastrointestinal prokinetic agent, primarily used for functional dyspepsia accompanied by gastrointestinal symptoms such as heartburn, belching, nausea, vomiting, early satiety, and upper abdominal distension. It can also be used for gastroesophageal reflux disease, diabetic gastroparesis, and gastric dysfunction in patients undergoing partial gastrectomy.
[Dosage and Administration]
Oral administration: 5 mg (1 tablet) three times daily before meals.
[Adverse Reactions]
Main symptoms include diarrhea, abdominal pain, dry mouth, rash, fatigue, and dizziness. Occasionally, eosinophilia, elevated triglycerides, and elevated aspartate aminotransferase (GOT), alanine aminotransferase (GPT), alkaline phosphatase (AKP), and gamma-glutamyl transpeptidase (GGT) may occur.
[Contraindications]
This product is contraindicated in patients with allergies.
[Precautions]
If gastrointestinal symptoms do not improve after a period of use (usually 2 weeks), discontinue use.
[Use in Special Populations]
Precautions for children:
Not yet available.
Precautions during pregnancy and lactation:
Unknown.
Precautions for the Elderly:
Seniors should be carefully monitored during medication use. Any side effects should be promptly addressed, such as reducing the dosage.
[Drug Interactions]
Combined use with anticholinergic drugs (such as atropine sulfate and butylscopolamine bromide) may weaken the efficacy of this drug.
[Pharmacological Actions]
This drug is a selective 5-hydroxytryptamine 4 (5-HT4) receptor agonist. By stimulating 5-HT4 receptors in gastrointestinal cholinergic interneurons and myenteric plexuses, it promotes acetylcholine release, thereby enhancing gastrointestinal motility and improving gastrointestinal symptoms in patients with functional dyspepsia. It does not affect gastric acid secretion. This drug has no affinity for dopamine D2, 5-HT1, and 5-HT2 receptors on brain synaptic membranes and, therefore, does not have the extrapyramidal side effects associated with blockade of these receptors. In toxicology studies, the oral LD50 of mosapride in mice was 2004 mg/kg, and the intraperitoneal LD50 was 587.77 mg/kg.
[Storage]
Store tightly closed in a cool, dry place.
[Specification]
5 mg
Packaging]
Aluminum-plastic packaging, 5 mg x 24s/box
[Expiry Date]
24 months
[Approval Number]
National Medicine Standard H20090158
[Manufacturer]
Yabao Pharmaceutical Group Co., Ltd.
