Product Overview
[Drug Name]
Generic Name: Lisinopril Tablets
Trade Name: Weiyiluo Lisinopril Tablets 10mg*14 Tablets
Pinyin Full Code: WeiYiLuo LaiNuoPuLiPian 10mg*14 Tablets
[Main Ingredients]
Main Ingredient: Lisinopril Tablets
[Appearance]
This product is white or off-white tablets or tinted tablets.
[Indications/Main Functions]
Hypertension: This product is used to treat essential hypertension and renovascular hypertension. It can be taken alone or in combination with other antihypertensive drugs. Congestive Heart Failure: This product can be used in combination with digitalis or diuretics as an adjunctive treatment for congestive heart failure. Acute Myocardial Infarction: This product is used to treat patients with hemodynamic stability within 24 hours after an acute myocardial infarction. It can prevent the development of left ventricular dysfunction or heart failure and improve survival. Patients should receive routine recommended treatments such as thrombolytics, aspirin, and beta-blockers, if appropriate.
[Specifications]
10mg x 14 tablets
[Dosage and Administration]
Because absorption of this product is not affected by food, it can be taken before, during, or after meals. This product should be taken orally once daily. (See package insert for details.)
[Adverse Reactions]
Controlled clinical trials have shown that this product is generally well tolerated. In most cases, side effects are mild and transient. The most common side effects reported in controlled trials were dizziness, headache, diarrhea, fatigue, cough, and nausea. Other less common side effects included orthostatic effects (including hypotension), rash, and asthenia. Allergy/Angioedema: Angioedema of the face, extremities, lips, tongue, glottis, and/or larynx has been reported occasionally (see "Precautions").
[Contraindications]
1. Hypersensitivity to any component of this product. 2. Patients who have previously experienced angioedema while receiving angiotensin-converting enzyme inhibitors. 3. Patients with solitary kidney, transplanted kidney, or renal impairment due to bilateral renal artery stenosis.
[Drug Interactions]
Diuretics: The concomitant use of a diuretic in patients receiving this medication often enhances its antihypertensive efficacy. In patients already taking, especially those who have recently taken, diuretics, the concomitant use of this medication may occasionally result in an excessive decrease in blood pressure. Discontinuing diuretics before starting this medication can reduce the likelihood of symptomatic hypotension (see [Precautions 1] and [Dosage and Administration]).
Precautions:
Symptomatic hypotension: Symptomatic hypotension is rare in patients with uncomplicated hypertension. It is more likely to occur in hypertensive patients receiving this medication in the presence of hypovolemia, such as diuretic therapy, a low-salt diet, dialysis, diarrhea, and vomiting (see [Adverse Reactions]). Symptomatic hypotension has been reported in patients with congestive heart failure, with or without renal insufficiency. The incidence of symptomatic hypotension is higher in patients with severe heart failure. This is more pronounced with high-dose diuretics, hyponatremia, or renal insufficiency. People who take this medicine should be treated under the guidance of a doctor, and the patient's condition should be observed at any time to adjust the dosage of this product and/or diuretics. At the same time, patients with ischemic heart disease or cerebrovascular disease should be considered. Excessive drop in blood pressure can lead to myocardial infarction or cerebrovascular accident. Once hypotension occurs, the patient should lie on his back and receive intravenous infusion of normal saline if necessary. A short-term hypotensive reaction is by no means a contraindication to continue taking the medicine. Once the blood pressure rises after volume expansion, it is usually feasible to continue taking the medicine. Taking this product will further lower the blood pressure in patients with congestive heart failure with normal or low blood pressure. This situation is expected and treatment does not need to be stopped. If If symptomatic hypotension occurs, the dosage of this drug may need to be reduced or treatment may need to be discontinued. (See package insert for details.)
[Pediatric Use]
The safety and efficacy of this drug have not been established in children.
[Elderly Use]
See the [Dosage and Administration] section.
[Overdose]
There are no data on human overdose. The most likely manifestation of an overdose is severe hypotension, which can be treated with regular intravenous saline infusion. Lisinopril can be removed by hemodialysis.
[Pharmacology and Toxicology]
Lisinopril is a peptide dipeptidase inhibitor. It inhibits angiotensin-converting enzyme (ACE), which is involved in It catalyzes the conversion of angiotensin II into the vasoconstrictor peptide angiotensin II. Angiotensin II stimulates the adrenal cortex to secrete aldosterone. ACE inhibition reduces angiotensin concentrations, thereby decreasing the pressor effect and aldosterone secretion. This decrease in aldosterone leads to an increase in serum potassium. Lisinopril lowers blood pressure primarily by inhibiting the renin-angiotensin-aldosterone system and also has antihypertensive effects in patients with low-renin hypertension. ACE is the same enzyme that degrades bradykinin, but whether increased levels of bradykinin (a vasodilator peptide) in the blood contribute to lisinopril's antihypertensive effect remains to be elucidated.
