Product Overview
[Drug name]
Generic name: Flumiphene citrate capsules
Trade name: BaiKeEn Flumiphene citrate capsules 50mg*15 tablets
Pinyin full code: BaiKeEn ZuoZuoSuanLvMiFenJiaoNang
[Main ingredients]
Chemical name: N,N-diethyl-2-[4-(1,2-diphenyl-2-chlorovinyl)phenoxy]ethylamine citrate of cis and trans isomers. Molecular formula: C26H28CINO·C6H8O7 Molecular weight: 598.09
[Properties]
This product is a capsule.
[Indications/Main functions]
Treatment of female infertility without ovulation, suitable for those with a certain level of estrogen in the body; treatment of corpus luteum insufficiency; testing ovarian function; detection of male hypothalamic-pituitary-gonadal axis dysfunction; treatment of male infertility due to low sperm count.
[Specification]
50mg*15 tablets (Bacon)
[Usage and Dosage]
Oral 50mg (1 tablet) per day for 5 days. Start taking the medicine from the 5th day of the menstrual cycle. If the patient is amenorrhea, the progesterone should be used on the 5th day of withdrawal bleeding. Patients who ovulate but do not conceive after treatment can repeat the original treatment course until conception, or repeat 3~4 courses. If the patient does not ovulate after treatment, the dose can be increased to 100mg (2 tablets) per day in the next course of treatment for a total of 5 days. Individual patients can ovulate only when the dose reaches 150mg (3 tablets) per day.
[Adverse Reactions]
1 Common adverse reactions include: swelling, stomach pain, pelvic or lower abdominal pain (ovarian enlargement or cyst formation or ovarian fibroma enlargement, more obvious ovarian enlargement, generally occurs a few days after stopping the drug). 2 Less common are: blurred vision, diplopia, flashes in front of the eyes, light sensitivity, decreased vision, yellowing of the skin and sclera. 3. Attention should be paid to the following reactions when they persist: hot flashes, breast discomfort, constipation or diarrhea, dizziness or vertigo, headache, increased menstrual flow or irregular bleeding, increased appetite and weight, hair loss, depression, mental tension, hyperactivity, insomnia, fatigue, nausea and vomiting, skin rash, allergic dermatitis, urticaria, frequent urination, etc., and weight loss may also occur. There are very few reports of breast cancer and testicular cancer abroad.
[Contraindications]
Unexplained irregular vaginal bleeding, uterine fibroids, ovarian cysts, liver damage, depression, thrombophlebitis, etc. are contraindicated.
[Use in elderly patients]
This experiment has not been conducted and there are no reliable references.
[Overdose]
This experiment has not been conducted and there are no reliable references.
[Pharmacology and toxicology]
Pharmacology: anti-hormone drug. The mechanism of this product stimulating ovulation is not yet fully understood. Since this product has a weak excitatory and strong antagonistic effect on estrogen, ovulation may be stimulated in the hypothalamus. First, antagonism is dominant. By competitively occupying the hypothalamic estrogen receptors, it interferes with the negative feedback of endogenous estrogen, promotes the secretion of luteinizing hormone and follicle-stimulating hormone, and then stimulates the growth of follicles. After the follicles mature, the release of estrogen increases, and the release of preovulatory gonadotropin is stimulated by positive feedback to reach a peak, so ovulation occurs. The treatment of male infertility may be related to the increase of FSH and LH and the promotion of sperm production. Toxicology: This experiment has not been conducted and there are no reliable references.
