Product Overview
【Drug Name】
Generic Name: Mecobalamin Tablets
Brand Name: Mecobalamin
English Name: Mecobalamin Tablets
Pinyin: Jiagu'an Pian
【Ingredients】
Main ingredient is mecobalamin.
【Appearance】
This product is a white sugar-coated tablet; after removing the sugar coating, it appears pink.
【Indications】
Peripheral neuropathy.
【Dosage and Administration】
Oral administration. The usual adult dose is one tablet (0.5mg) three times a day. The dosage may be adjusted according to age and symptoms.
【Adverse Reactions】
1. Allergic reaction: Occasionally, a rash may occur (incidence rate 0.1%). Discontinue use if this occurs.
2. Other: Occasionally (incidence rate 5%–0.1%), loss of appetite, nausea, vomiting, and diarrhea.
【Contraindications】
Contraindicated in patients with a history of allergy to mecobalamin or any of the excipients in the prescription.
【Precautions】
1. If there is no effect after one month of use, discontinue use.
2. Workers exposed to mercury and its compounds should not take this product in large quantities or for extended periods.
3. After opening, this product should be stored away from light and moisture.
【Special Populations】
Precautions for Children: Follow your doctor's instructions.
Precautions for Pregnancy and Lactation: Although mecobalamin has not shown teratogenic effects in animal studies, its safety in pregnant women is unclear. It is unclear whether mecobalamin is excreted in breast milk, but animal studies have reported its excretion in breast milk. The safety of this product in lactating women is unclear.
Precautions for the Elderly: Due to decreased function in the elderly, it is recommended to reduce the dosage appropriately under the guidance of a doctor.
【Drug Interactions】
No such experiments have been conducted and there are no reliable references.
【Pharmacological Action】
This product is an endogenous coenzyme B12 that participates in the one-carbon unit cycle and plays an important role in the transmethylation reaction of homocysteine to methionine. Animal experiments have shown that this product enters neuronal organelles more readily than cyanocobalamin, participating in the synthesis of thymidine in brain cells and spinal cord neurons, promoting folic acid utilization and nucleic acid metabolism, and exhibiting a stronger effect in promoting nucleic acid and protein synthesis than cyanocobalamin. This product can promote axonal transport and regeneration, normalizing the transport of sciatic nerve axonal skeletal proteins in streptozotocin-induced diabetic rats, and inhibiting drug-induced neurodegeneration, such as that induced by doxorubicin, acrylamide, vincristine, and neurological diseases in spontaneously hypertensive rats. In rat tissue culture, this product has been found to promote lecithin synthesis and neuronal myelination. This product can restore delayed synaptic transmission and reduced neurotransmitter levels to normal, and restores endplate potential induction by increasing nerve fiber excitability, restoring acetylcholine levels in the brains of rats fed a choline-deficient diet to normal levels. Toxicological studies on reproductive toxicity: Oral administration of this product at doses of 0.2, 2.0, and 20 mg/kg/day to rats and mice during the teratogenic sensitive period did not result in any abnormalities or teratogenic signs in fetuses or newborns.
【Storage】
Store protected from light and in a tightly closed container.
【Specifications】
0.5 mg
【Packaging】
Aluminum-plastic packaging. 10 tablets/blister * 2 blisters/box
【Shelf Life】
24 months
【Approval Number】
National Drug Approval Number H20030812
【Manufacturer】
Eisai (China) Pharmaceutical Co., Ltd.
