Product Overview
【Drug Name】
Generic Name: Mecobalamin Tablets
Brand Name: Bokebao
English Name: Mecobalamin Tablets
Pinyin: Jiagu'an Pian
【Ingredients】
Mecobalamin, its chemical name is: -(5,6-dimethylbenzimidazolyl)-Co-methylcobalaminamide. Molecular formula: C63H91CoN13O14P, molecular weight: 1344.40.
【Appearance】
This product is a brown film-coated tablet, which appears light red after removing the film coating.
【Indications】
Peripheral neuropathy.
【Dosage and Administration】
Oral administration. The usual adult dose is one tablet (0.5mg) three times a day. The dosage may be increased or decreased according to age and symptoms.
【Adverse Reactions】
1. Allergic reaction: Occasionally, a rash may occur (incidence rate 0.1%). If this occurs, discontinue use.
2. Other: Occasionally (incidence rate 5%–0.1%), loss of appetite, nausea, vomiting, diarrhea.
【Contraindications】
This product is contraindicated in patients with a history of allergy to mecobalamin or any of the excipients in the prescription.
【Precautions】
1. If ineffective after one month of use, discontinue use.
2. Workers exposed to mercury and its compounds should not take this product in large quantities or for extended periods.
3. Once opened, this product should be stored away from light and moisture.
【Special Populations】
Children: Follow doctor's instructions.
Pregnancy and Lactation: Although mecobalamin has not shown teratogenic effects in animal studies, its safety in pregnant women is unclear. It is unclear whether mecobalamin is excreted in breast milk, but animal studies have reported its excretion in breast milk. The safety of this product in lactating women is unclear.
Elderly: Due to decreased function in the elderly, it is recommended to reduce the dosage as appropriate under the guidance of a doctor.
【Drug Interactions】
Not yet clear.
【Pharmacological Action】
This product is an endogenous coenzyme B12 that participates in the one-carbon unit cycle and plays an important role in the transmethylation reaction of homocysteine to methionine. Animal experiments have shown that this product enters neuronal organelles more readily than cyanocobalamin, participating in the synthesis of thymidine in brain and spinal cord neurons, promoting folic acid utilization and nucleic acid metabolism, and exhibiting a stronger effect in promoting nucleic acid and protein synthesis than cyanocobalamin. This product can promote axonal transport and regeneration, normalizing the transport of sciatic nerve axonal skeletal proteins in streptozotocin-induced diabetic rats, and inhibiting drug-induced neurodegeneration, such as that induced by doxorubicin, acrylamide, and vincristine, as well as neurological diseases in spontaneously hypertensive rats. In rat tissue culture, this product has been found to promote lecithin synthesis and neuronal myelination. This product can restore delayed synaptic transmission and reduced neurotransmitter levels to normal, and restores the induction of complex endplate potentials by increasing nerve fiber excitability, thus restoring acetylcholine levels in the brains of rats fed a choline-deficient diet to normal levels.
【Storage】
Store protected from light and in a sealed container.
【Specifications】
0.5mg
【Shelf Life】
24 months
【Approval Number】
National Drug Approval Number H20050997
【Manufacturer】
Hainan Sida Pharmaceutical Co., Ltd.
